Method and apparatus for monitoring development of medication induced side effects

ABSTRACT

Systems and methods for home monitoring and detection of febrile neutropenia in a patient are provided. The system includes a photoplethysmographic sensor for sensing photoplethysmographic signals of the patient, and one or more blood borne parameter sensors for sensing parameters in the patient&#39;s blood. A febrile neutropenia monitoring application receives information sensed by the photoplethysmography sensor and the one or more blood borne parameter sensors and determines, based on the received information, the presence or deterioration of febrile neutropenia. The method includes the steps of: sensing photoplethysmographic signals of the patient with a photoplethysmographic sensor worn by the patient; sensing blood borne parameters in the patient&#39;s blood with one or more blood borne parameter sensors; transmitting the sensed photoplethysmographic signals and blood borne parameters to a febrile neutropenia monitoring application; and determining, by the febrile neutropenia monitoring application, the presence or deterioration of febrile neutropenia based on the received information.

CROSS REFERENCE TO RELATED APPLICATIONS

This application is a continuation-in-part of my co-pending U.S. patent application Ser. No. 16/436,035, filed Jun. 10, 2019, which is turn is a continuation application of U.S. patent application Ser. No. 14/333,341, filed Jul. 16, 2014, now U.S. Pat. No. 10,314,549, granted Jun. 11, 2019, which in turn, claims priority from U.S. Provisional Application Ser. No. 61/846,980, filed Jul. 16, 2013, the contents of which are incorporated herein by reference.

FIELD OF THE INVENTION

The present disclosure is generally related to home monitoring of a patient's health, and more particularly is related to systems and methods home monitoring and detection of medication induced side effects in a patient.

BACKGROUND OF THE INVENTION

Various drugs and drug combinations currently are used in treating cancer. These drugs include

-   -   5-FU (Fluorouracil Injection) indicated for Breast Cancer     -   5-FU (Fluorouracil Injection) indicated for Colon Cancer     -   5-FU (Fluorouracil Injection) indicated for Gastric Cancer     -   5-FU (Fluorouracil Injection) indicated for Pancreatic Cancer     -   5-FU (Fluorouracil Injection) indicated for Rectal Cancer     -   5-FU (Fluorouracil—Topical) indicated for Basal Cell Carcinoma     -   Abecma (Idecabtagene Vicleucel) indicated for Multiple Myeloma     -   Abemaciclib indicated for Breast Cancer     -   Abiraterone Acetate indicated for Prostate Cancer     -   Abraxane (Paclitaxel Albumin-stabilized Nanoparticle         Formulation) indicated for Breast Cancer     -   Abraxane (Paclitaxel Albumin-stabilized Nanoparticle         Formulation) indicated for Non-Small Cell Lung Cancer     -   Abraxane (Paclitaxel Albumin-stabilized Nanoparticle         Formulation) indicated for Pancreatic Cancer     -   Acalabrutinib indicated for Chronic Lymphocytic Leukemia     -   Acalabrutinib indicated for Non-Hodgkin Lymphoma     -   Adcetris (Brentuximab Vedotin) indicated for Hodgkin Lymphoma     -   Adcetris (Brentuximab Vedotin) indicated for Non-Hodgkin         Lymphoma     -   Ado-Trastuzumab Emtansine indicated for Breast Cancer     -   Adriamycin PFS (Doxorubicin Hydrochloride) indicated for         Myeloproliferative Neoplasms     -   Adriamycin RDF (Doxorubicin Hydrochloride) indicated for         Myeloproliferative Neoplasms     -   Afatinib Dimaleate indicated for Non-Small Cell Lung Cancer     -   Afinitor (Everolimus) indicated for Brain Tumors     -   Afinitor (Everolimus) indicated for Breast Cancer     -   Afinitor (Everolimus) indicated for Gastroenteropancreatic         Neuroendocrine Tumors     -   Afinitor (Everolimus) indicated for Non-Small Cell Lung Cancer     -   Afinitor (Everolimus) indicated for Pancreatic Cancer     -   Afinitor (Everolimus) indicated for Renal Cell Cancer     -   Afinitor (Everolimus) indicated for Small Cell Lung Cancer     -   Afinitor Disperz (Everolimus) indicated for Brain Tumors     -   Afinitor Disperz (Everolimus) indicated for Breast Cancer     -   Afinitor Disperz (Everolimus) indicated for         Gastroenteropancreatic Neuroendocrine Tumors     -   Afinitor Disperz (Everolimus) indicated for Non-Small Cell Lung         Cancer     -   Afinitor Disperz (Everolimus) indicated for Renal Cell Cancer     -   Aldara (Imiquimod) indicated for Basal Cell Carcinoma     -   Aldesleukin indicated for Melanoma     -   Aldesleukin indicated for Melanoma     -   Aldesleukin indicated for Renal Cell Cancer     -   Alecensa (Alectinib) indicated for Non-Small Cell Lung Cancer     -   Alectinib indicated for Non-Small Cell Lung Cancer     -   Alemtuzumab indicated for Chronic Lymphocytic Leukemia     -   Alimta (Pemetrexed Disodium) indicated for Malignant         Mesothelioma     -   Alimta (Pemetrexed Disodium) indicated for Non-Small Cell Lung         Cancer     -   Aliqopa (Copanlisib Hydrochloride) indicated for Non-Hodgkin         Lymphoma     -   Alkeran (Melphalan) indicated for Ovarian Cancer     -   Alkeran for Injection (Melphalan Hydrochloride) indicated for         Multiple Myeloma     -   Alkeran Tablets (Melphalan) indicated for Multiple Myeloma     -   Alpelisib indicated for Breast Cancer     -   Alunbrig (Brigatinib) indicated for Non-Small Cell Lung Cancer     -   Anastrozole indicated for Breast Cancer     -   Apalutamide indicated for Prostate Cancer     -   Aredia (Pamidronate Disodium) indicated for Breast Cancer     -   Aredia (Pamidronate Disodium) indicated for Multiple Myeloma     -   Arimidex (Anastrozole) indicated for Breast Cancer     -   Aromasin (Exemestane) indicated for Breast Cancer     -   Arranon (Nelarabine) indicated for Acute Lymphoblastic Leukemia     -   Arranon (Nelarabine) indicated for Non-Hodgkin Lymphoma     -   Arsenic Trioxide indicated for Acute Myeloid Leukemia     -   Arsenic Trioxide indicated for Myeloproliferative Neoplasms     -   Arzerra (Ofatumumab) indicated for Chronic Lymphocytic Leukemia     -   Asparaginase Erwinia chrysanthemi indicated for Acute         Lymphoblastic Leukemia     -   Asparlas (Calaspargase Pegol-mknl) indicated for Acute         Lymphoblastic Leukemia     -   Atezolizumab indicated for Bladder Cancer     -   Atezolizumab indicated for Breast Cancer     -   Atezolizumab indicated for Liver Cancer     -   Atezolizumab indicated for Non-Small Cell Lung Cancer     -   Atezolizumab indicated for Small Cell Lung Cancer     -   Avapritinib indicated for Gastrointestinal Stromal Tumors     -   Avastin (Bevacizumab) indicated for Brain Tumors     -   Avastin (Bevacizumab) indicated for Cervical Cancer     -   Avastin (Bevacizumab) indicated for Colon Cancer     -   Avastin (Bevacizumab) indicated for Liver Cancer     -   Avastin (Bevacizumab) indicated for Non-Small Cell Lung Cancer     -   Avastin (Bevacizumab) indicated for Ovarian Cancer     -   Avastin (Bevacizumab) indicated for Rectal Cancer     -   Avastin (Bevacizumab) indicated for Renal Cell Cancer     -   Avelumab indicated for Bladder Cancer     -   Avelumab indicated for Merkel Cell Carcinoma     -   Avelumab indicated for Renal Cell Cancer     -   Axicabtagene Ciloleucel indicated for Non-Hodgkin Lymphoma     -   Axitinib indicated for Renal Cell Cancer     -   Ayvakit (Avapritinib) indicated for Gastrointestinal Stromal         Tumors     -   Azacitidine indicated for Acute Myeloid Leukemia     -   Azacitidine indicated for Myeloproliferative Neoplasms     -   Azedra (Iobenguane I 131) indicated for Paraganglioma     -   Azedra (Iobenguane I 131) indicated for Pheochromocytoma     -   Balversa (Erdafitinib) indicated for Bladder Cancer     -   Bavencio (Avelumab) indicated for Bladder Cancer     -   Bavencio (Avelumab) indicated for Merkel Cell Carcinoma     -   Bavencio (Avelumab) indicated for Renal Cell Cancer     -   Belantamab Mafodotin-blmf indicated for Multiple Myeloma     -   Beleodaq (Belinostat) indicated for Non-Hodgkin Lymphoma     -   Belinostat indicated for Non-Hodgkin Lymphoma     -   Bendamustine Hydrochloride indicated for Chronic Lymphocytic         Leukemia     -   Bendamustine Hydrochloride indicated for Non-Hodgkin Lymphoma     -   Bendeka (Bendamustine Hydrochloride) indicated for Chronic         Lymphocytic Leukemia     -   Bendeka (Bendamustine Hydrochloride) indicated for Non-Hodgkin         Lymphoma     -   Besponsa (Inotuzumab Ozogamicin) indicated for Acute         Lymphoblastic Leukemia     -   Bevacizumab indicated for Brain Tumors     -   Bevacizumab indicated for Cervical Cancer     -   Bevacizumab indicated for Colon Cancer     -   Bevacizumab indicated for Liver Cancer     -   Bevacizumab indicated for Non-Small Cell Lung Cancer     -   Bevacizumab indicated for Ovarian Cancer     -   Bevacizumab indicated for Rectal Cancer     -   Bevacizumab indicated for Renal Cell Cancer     -   Bicalutamide indicated for Prostate Cancer     -   BiCNU (Carmustine) indicated for Brain Tumors     -   BiCNU (Carmustine) indicated for Hodgkin Lymphoma     -   BiCNU (Carmustine) indicated for Multiple Myeloma     -   BiCNU (Carmustine) indicated for Non-Hodgkin Lymphoma     -   Binimetinib indicated for Melanoma     -   Blenrep (Belantamab Mafodotin-blmf) indicated for Multiple         Myeloma     -   Bleomycin Sulfate indicated for Cervical Cancer     -   Bleomycin Sulfate indicated for Head and Neck Cancer     -   Bleomycin Sulfate indicated for Hodgkin Lymphoma     -   Bleomycin Sulfate indicated for Non-Hodgkin Lymphoma     -   Bleomycin Sulfate indicated for Penile Cancer     -   Bleomycin Sulfate indicated for Testicular Cancer     -   Bleomycin Sulfate indicated for Vulvar Cancer     -   Blinatumomab indicated for Acute Lymphoblastic Leukemia     -   Blincyto (Blinatumomab) indicated for Acute Lymphoblastic         Leukemia     -   Bortezomib indicated for Multiple Myeloma     -   Bortezomib indicated for Non-Hodgkin Lymphoma     -   Bosulif (Bosutinib) indicated for Chronic Myelogenous Leukemia     -   Bosutinib indicated for Chronic Myelogenous Leukemia     -   Braftovi (Encorafenib) indicated for Melanoma     -   Brentuximab Vedotin indicated for Hodgkin Lymphoma     -   Brentuximab Vedotin indicated for Non-Hodgkin Lymphoma     -   Brexucabtagene Autoleucel indicated for Non-Hodgkin Lymphoma     -   Breyanzi (Lisocabtagene Maraleucel) indicated for Non-Hodgkin         Lymphoma     -   Brigatinib indicated for Non-Small Cell Lung Cancer     -   Brukinsa (Zanubrutinib) indicated for Non-Hodgkin Lymphoma     -   Busulfan indicated for Chronic Myelogenous Leukemia     -   Busulfex (Busulfan) indicated for Chronic Myelogenous Leukemia     -   Cabazitaxel indicated for Prostate Cancer     -   Cabometyx (Cabozantinib-S-Malate) indicated for Liver Cancer     -   Cabometyx (Cabozantinib-S-Malate) indicated for Renal Cell         Cancer     -   Cabozantinib-S-Malate indicated for Liver Cancer     -   Cabozantinib-S-Malate indicated for Renal Cell Cancer     -   Cabozantinib-S-Malate indicated for Thyroid Cancer     -   Calaspargase Pegol-mknl indicated for Acute Lymphoblastic         Leukemia     -   Calquence (Acalabrutinib) indicated for Chronic Lymphocytic         Leukemia     -   Calquence (Acalabrutinib) indicated for Non-Hodgkin Lymphoma     -   Campath (Alemtuzumab) indicated for Chronic Lymphocytic Leukemia     -   Camptosar (Irinotecan Hydrochloride) indicated for Colon Cancer     -   Camptosar (Irinotecan Hydrochloride) indicated for Rectal Cancer     -   Capecitabine indicated for Breast Cancer     -   Capecitabine indicated for Colon Cancer     -   Capecitabine indicated for Rectal Cancer     -   Capmatinib Hydrochloride indicated for Non-Small Cell Lung         Cancer     -   Caprelsa (Vandetanib) indicated for Thyroid Cancer     -   Carboplatin indicated for Non-Small Cell Lung Cancer     -   Carboplatin indicated for Ovarian Cancer     -   Carfilzomib indicated for Multiple Myeloma     -   Carmustine Implant indicated for Brain Tumors     -   Carmustine indicated for Brain Tumors     -   Carmustine indicated for Hodgkin Lymphoma     -   Carmustine indicated for Multiple Myeloma     -   Carmustine indicated for Non-Hodgkin Lymphoma     -   Casodex (Bicalutamide) indicated for Prostate Cancer     -   Cemiplimab-rwlc indicated for Basal Cell Carcinoma     -   Cemiplimab-rwlc indicated for Cutaneous Squamous Cell Carcinoma     -   Cemiplimab-rwlc indicated for Non-Small Cell Lung Cancer     -   Ceritinib indicated for Non-Small Cell Lung Cancer     -   Cerubidine (Daunorubicin Hydrochloride) indicated for Acute         Lymphoblastic Leukemia     -   Cerubidine (Daunorubicin Hydrochloride) indicated for Acute         Myeloid Leukemia     -   Cerubidine (Daunorubicin Hydrochloride) indicated for         Myeloproliferative Neoplasms     -   Cetuximab indicated for Colon Cancer     -   Cetuximab indicated for Head and Neck Cancer     -   Cetuximab indicated for Rectal Cancer     -   Chlorambucil indicated for Chronic Lymphocytic Leukemia     -   Chlorambucil indicated for Hodgkin Lymphoma     -   Chlorambucil indicated for Non-Hodgkin Lymphoma     -   Cisplatin indicated for Bladder Cancer     -   Cisplatin indicated for Ovarian Cancer     -   Cisplatin indicated for Testicular Cancer     -   Cladribine indicated for Hairy Cell Leukemia     -   Clafen (Cyclophosphamide) indicated for Myeloproliferative         Neoplasms     -   Clofarabine indicated for Acute Lymphoblastic Leukemia     -   Clolar (Clofarabine) indicated for Acute Lymphoblastic Leukemia     -   Cobimetinib Fumarate indicated for Melanoma     -   Cobimetinib indicated for Melanoma     -   Cometriq (Cabozantinib-S-Malate) indicated for Thyroid Cancer     -   Copanlisib Hydrochloride indicated for Non-Hodgkin Lymphoma     -   Copiktra (Duvelisib) indicated for Chronic Lymphocytic Leukemia     -   Copiktra (Duvelisib) indicated for Non-Hodgkin Lymphoma     -   Cosmegen (Dactinomycin) indicated for Bone Cancer     -   Cosmegen (Dactinomycin) indicated for Childhood Kidney Cancers     -   Cosmegen (Dactinomycin) indicated for Gestational Trophoblastic         Disease     -   Cosmegen (Dactinomycin) indicated for Rhabdomyosarcoma     -   Cosmegen (Dactinomycin) indicated for Soft Tissue Sarcoma     -   Cosmegen (Dactinomycin) indicated for Testicular Cancer     -   Cotellic (Cobimetinib Fumarate) indicated for Melanoma     -   Cotellic (Cobimetinib) indicated for Melanoma     -   Crizotinib indicated for Non-Hodgkin Lymphoma     -   Crizotinib indicated for Non-Small Cell Lung Cancer     -   Cyclophosphamide indicated for Acute Lymphoblastic Leukemia     -   Cyclophosphamide indicated for Acute Myeloid Leukemia     -   Cyclophosphamide indicated for Breast Cancer     -   Cyclophosphamide indicated for Chronic Lymphocytic Leukemia     -   Cyclophosphamide indicated for Chronic Myelogenous Leukemia     -   Cyclophosphamide indicated for Hodgkin Lymphoma     -   Cyclophosphamide indicated for Multiple Myeloma     -   Cyclophosphamide indicated for Myeloproliferative Neoplasms     -   Cyclophosphamide indicated for Neuroblastoma     -   Cyclophosphamide indicated for Non-Hodgkin Lymphoma     -   Cyclophosphamide indicated for Ovarian Cancer     -   Cyclophosphamide indicated for Retinoblastoma     -   Cyramza (Ramucirumab) indicated for Colon Cancer     -   Cyramza (Ramucirumab) indicated for Gastric Cancer     -   Cyramza (Ramucirumab) indicated for Gastroesophageal Junction         Cancer     -   Cyramza (Ramucirumab) indicated for Liver Cancer     -   Cyramza (Ramucirumab) indicated for Non-Small Cell Lung Cancer     -   Cyramza (Ramucirumab) indicated for Rectal Cancer     -   Cytarabine indicated for Acute Lymphoblastic Leukemia     -   Cytarabine indicated for Acute Myeloid Leukemia     -   Cytarabine indicated for Chronic Myelogenous Leukemia     -   Cytarabine indicated for Meningeal Leukemia     -   Cytarabine indicated for Myeloproliferative Neoplasms     -   Cytosar-U (Cytarabine) indicated for Myeloproliferative         Neoplasms     -   Cytoxan (Cyclophosphamide) indicated for Myeloproliferative         Neoplasms     -   Dabrafenib indicated for Melanoma     -   Dabrafenib Mesylate indicated for Melanoma     -   Dabrafenib Mesylate indicated for Non-Small Cell Lung Cancer     -   Dabrafenib Mesylate indicated for Thyroid Cancer     -   Dacarbazine indicated for Hodgkin Lymphoma     -   Dacarbazine indicated for Melanoma     -   Dacarbazine indicated for Melanoma     -   Dacogen (Decitabine) indicated for Myeloproliferative Neoplasms     -   Dacomitinib indicated for Non-Small Cell Lung Cancer     -   Dactinomycin indicated for Bone Cancer     -   Dactinomycin indicated for Childhood Kidney Cancers     -   Dactinomycin indicated for Gestational Trophoblastic Disease     -   Dactinomycin indicated for Rhabdomyosarcoma     -   Dactinomycin indicated for Soft Tissue Sarcoma     -   Dactinomycin indicated for Testicular Cancer     -   Danyelza (Naxitamab-gqgk) indicated for Brain Tumors     -   Danyelza (Naxitamab-gqgk) indicated for Neuroblastoma     -   Daratumumab and Hyaluronidase-fihj indicated for Multiple         Myeloma     -   Daratumumab indicated for Multiple Myeloma     -   Darolutamide indicated for Prostate Cancer     -   Darzalex (Daratumumab) indicated for Multiple Myeloma     -   Darzalex Faspro (Daratumumab and Hyaluronidase-fihj) indicated         for Multiple Myeloma     -   Dasatinib indicated for Acute Lymphoblastic Leukemia     -   Dasatinib indicated for Chronic Myelogenous Leukemia     -   Dasatinib indicated for Myeloproliferative Neoplasms     -   Daunorubicin Hydrochloride and Cytarabine Liposome indicated for         Acute Myeloid Leukemia     -   Daunorubicin Hydrochloride indicated for Acute Lymphoblastic         Leukemia     -   Daunorubicin Hydrochloride indicated for Acute Myeloid Leukemia     -   Daunorubicin Hydrochloride indicated for Myeloproliferative         Neoplasms     -   Daurismo (Glasdegib Maleate) indicated for Acute Myeloid         Leukemia     -   Decitabine and Cedazuridine indicated for Myeloproliferative         Neoplasms     -   Decitabine indicated for Myeloproliferative Neoplasms     -   Degarelix indicated for Prostate Cancer     -   Denileukin Diftitox indicated for Non-Hodgkin Lymphoma     -   Denosumab indicated for Bone Cancer     -   Dexamethasone indicated for Acute Lymphoblastic Leukemia     -   Dexamethasone indicated for Acute Myeloid Leukemia     -   Dexamethasone indicated for Chronic Lymphocytic Leukemia     -   Dexamethasone indicated for Chronic Myelogenous Leukemia     -   Dexamethasone indicated for Hodgkin Lymphoma     -   Dexamethasone indicated for Non-Hodgkin Lymphoma     -   Dinutuximab indicated for Neuroblastoma     -   Docetaxel indicated for Breast Cancer     -   Docetaxel indicated for Gastric Cancer     -   Docetaxel indicated for Gastroesophageal Junction Cancer     -   Docetaxel indicated for Head and Neck Cancer     -   Docetaxel indicated for Non-Small Cell Lung Cancer     -   Docetaxel indicated for Prostate Cancer     -   Dostarlimab-gxly indicated for Endometrial Cancer     -   Doxil (Doxorubicin Hydrochloride Liposome) indicated for Kaposi         Sarcoma     -   Doxil (Doxorubicin Hydrochloride Liposome) indicated for         Multiple Myeloma     -   Doxil (Doxorubicin Hydrochloride Liposome) indicated for Ovarian         Cancer     -   Doxorubicin Hydrochloride indicated for Acute Lymphoblastic         Leukemia     -   Doxorubicin Hydrochloride indicated for Acute Myeloid Leukemia     -   Doxorubicin Hydrochloride indicated for Bladder Cancer     -   Doxorubicin Hydrochloride indicated for Bone Cancer     -   Doxorubicin Hydrochloride indicated for Breast Cancer     -   Doxorubicin Hydrochloride indicated for Childhood Kidney Cancers     -   Doxorubicin Hydrochloride indicated for Gastric Cancer     -   Doxorubicin Hydrochloride indicated for Hodgkin Lymphoma     -   Doxorubicin Hydrochloride indicated for Myeloproliferative         Neoplasms     -   Doxorubicin Hydrochloride indicated for Neuroblastoma     -   Doxorubicin Hydrochloride indicated for Non-Hodgkin Lymphoma     -   Doxorubicin Hydrochloride indicated for Non-Small Cell Lung         Cancer     -   Doxorubicin Hydrochloride indicated for Ovarian Cancer     -   Doxorubicin Hydrochloride indicated for Small Cell Lung Cancer     -   Doxorubicin Hydrochloride indicated for Soft Tissue Sarcoma     -   Doxorubicin Hydrochloride indicated for Thyroid Cancer     -   Doxorubicin Hydrochloride Liposome indicated for Kaposi Sarcoma     -   Doxorubicin Hydrochloride Liposome indicated for Multiple         Myeloma     -   Doxorubicin Hydrochloride Liposome indicated for Ovarian Cancer     -   DTIC-Dome (Dacarbazine) indicated for Melanoma     -   Durvalumab indicated for Non-Small Cell Lung Cancer     -   Durvalumab indicated for Small Cell Lung Cancer     -   Duvelisib indicated for Chronic Lymphocytic Leukemia     -   Duvelisib indicated for Non-Hodgkin Lymphoma     -   Efudex (Fluorouracil—Topical) indicated for Basal Cell Carcinoma     -   Eligard (Leuprolide Acetate) indicated for Prostate Cancer     -   Ellence (Epirubicin Hydrochloride) indicated for Breast Cancer     -   Elotuzumab indicated for Multiple Myeloma     -   Eloxatin (Oxaliplatin) indicated for Colon Cancer     -   Eloxatin (Oxaliplatin) indicated for Rectal Cancer     -   Elzonris (Tagraxofusp-erzs) indicated for Blastic Plasmacytoid         Dendritic Cell Neoplasm     -   Empliciti (Elotuzumab) indicated for Multiple Myeloma     -   Enasidenib Mesylate indicated for Acute Myeloid Leukemia     -   Encorafenib indicated for Melanoma     -   Enfortumab Vedotin-ejfv indicated for Bladder Cancer     -   Enhertu (Fam-Trastuzumab Deruxtecan-nxki) indicated for Breast         Cancer     -   Enhertu (Fam-Trastuzumab Deruxtecan-nxki) indicated for Gastric         Cancer     -   Enhertu (Fam-Trastuzumab Deruxtecan-nxki) indicated for         Gastroesophageal Junction Cancer     -   Entrectinib indicated for All Solid Tumors     -   Entrectinib indicated for Non-Small Cell Lung Cancer     -   Enzalutamide indicated for Prostate Cancer     -   Epirubicin Hydrochloride indicated for Breast Cancer     -   Erbitux (Cetuximab) indicated for Colon Cancer     -   Erbitux (Cetuximab) indicated for Head and Neck Cancer     -   Erbitux (Cetuximab) indicated for Rectal Cancer     -   Erdafitinib indicated for Bladder Cancer     -   Eribulin Mesylate indicated for Breast Cancer     -   Eribulin Mesylate indicated for Soft Tissue Sarcoma     -   Erivedge (Vismodegib) indicated for Basal Cell Carcinoma     -   Erleada (Apalutamide) indicated for Prostate Cancer     -   Erlotinib Hydrochloride indicated for Non-Small Cell Lung Cancer     -   Erlotinib Hydrochloride indicated for Pancreatic Cancer     -   Erwinaze (Asparaginase Erwinia Chrysanthemi) indicated for Acute         Lymphoblastic Leukemia     -   Etopophos (Etoposide Phosphate) indicated for Small Cell Lung         Cancer     -   Etopophos (Etoposide Phosphate) indicated for Testicular Cancer     -   Etoposide indicated for Small Cell Lung Cancer     -   Etoposide indicated for Testicular Cancer     -   Etoposide Phosphate indicated for Small Cell Lung Cancer     -   Etoposide Phosphate indicated for Testicular Cancer     -   Everolimus indicated for Brain Tumors     -   Everolimus indicated for Breast Cancer     -   Everolimus indicated for Gastroenteropancreatic Neuroendocrine         Tumors     -   Everolimus indicated for Non-Small Cell Lung Cancer     -   Everolimus indicated for Pancreatic Cancer     -   Everolimus indicated for Renal Cell Cancer     -   Everolimus indicated for Small Cell Lung Cancer     -   Evomela (Melphalan Hydrochloride) indicated for Multiple Myeloma     -   Exemestane indicated for Breast Cancer     -   Fam-Trastuzumab Deruxtecan-nxki indicated for Breast Cancer     -   Fam-Trastuzumab Deruxtecan-nxki indicated for Gastric Cancer     -   Fam-Trastuzumab Deruxtecan-nxki indicated for Gastroesophageal         Junction Cancer     -   Fareston (Toremifene) indicated for Breast Cancer     -   Farydak (Panobinostat Lactate) indicated for Multiple Myeloma     -   Faslodex (Fulvestrant) indicated for Breast Cancer     -   Fedratinib Hydrochloride indicated for Myeloproliferative         Neoplasms     -   Femara (Letrozole) indicated for Breast Cancer     -   Firmagon (Degarelix) indicated for Prostate Cancer     -   Fludarabine Phosphate indicated for Chronic Lymphocytic Leukemia     -   Fluorouracil Injection indicated for Breast Cancer     -   Fluorouracil Injection indicated for Colon Cancer     -   Fluorouracil Injection indicated for Gastric Cancer     -   Fluorouracil Injection indicated for Pancreatic Cancer     -   Fluorouracil Injection indicated for Rectal Cancer     -   Fluorouracil—Topical indicated for Basal Cell Carcinoma     -   Flutamide indicated for Prostate Cancer     -   Folotyn (Pralatrexate) indicated for Non-Hodgkin Lymphoma     -   Fotivda (Tivozanib Hydrochloride) indicated for Renal Cell         Cancer     -   Fulvestrant indicated for Breast Cancer     -   Gavreto (Pralsetinib) indicated for Non-Small Cell Lung Cancer     -   Gavreto (Pralsetinib) indicated for Thyroid Cancer     -   Gazyva (Obinutuzumab) indicated for Chronic Lymphocytic Leukemia     -   Gazyva (Obinutuzumab) indicated for Non-Hodgkin Lymphoma     -   Gefitinib indicated for Non-Small Cell Lung Cancer     -   Gemcitabine Hydrochloride indicated for Breast Cancer     -   Gemcitabine Hydrochloride indicated for Non-Small Cell Lung         Cancer     -   Gemcitabine Hydrochloride indicated for Ovarian Cancer     -   Gemcitabine Hydrochloride indicated for Pancreatic Cancer     -   Gemtuzumab Ozogamicin indicated for Acute Myeloid Leukemia     -   Gemzar (Gemcitabine Hydrochloride) indicated for Breast Cancer     -   Gemzar (Gemcitabine Hydrochloride) indicated for Non-Small Cell         Lung Cancer     -   Gemzar (Gemcitabine Hydrochloride) indicated for Ovarian Cancer     -   Gemzar (Gemcitabine Hydrochloride) indicated for Pancreatic         Cancer     -   Gilotrif (Afatinib Dimaleate) indicated for Non-Small Cell Lung         Cancer     -   Gilteritinib Fumarate indicated for Acute Myeloid Leukemia     -   Glasdegib Maleate indicated for Acute Myeloid Leukemia     -   Gleevec (Imatinib Mesylate) indicated for Acute Lymphoblastic         Leukemia     -   Gleevec (Imatinib Mesylate) indicated for Chronic Myelogenous         Leukemia     -   Gleevec (Imatinib Mesylate) indicated for Gastrointestinal         Stromal Tumors     -   Gleevec (Imatinib Mesylate) indicated for Myeloproliferative         Neoplasms     -   Gleevec (Imatinib Mesylate) indicated for Soft Tissue Sarcoma     -   Gliadel Wafer (Carmustine Implant) indicated for Brain Tumors     -   Goserelin Acetate indicated for Breast Cancer     -   Goserelin Acetate indicated for Prostate Cancer     -   Halaven (Eribulin Mesylate) indicated for Breast Cancer     -   Halaven (Eribulin Mesylate) indicated for Soft Tissue Sarcoma     -   Hemangeol (Propranolol Hydrochloride) indicated for         Pheochromocytoma     -   Herceptin (Trastuzumab) indicated for Breast Cancer     -   Herceptin (Trastuzumab) indicated for Gastric Cancer     -   Herceptin (Trastuzumab) indicated for Gastroesophageal Junction         Cancer     -   Herceptin Hylecta (Trastuzumab and Hyaluronidase-oysk) indicated         for Breast Cancer     -   Hycamtin (Topotecan Hydrochloride) indicated for Cervical Cancer     -   Hycamtin (Topotecan Hydrochloride) indicated for Ovarian Cancer     -   Hycamtin (Topotecan Hydrochloride) indicated for Small Cell Lung         Cancer     -   Hydrea (Hydroxyurea) indicated for Chronic Myelogenous Leukemia     -   Hydrea (Hydroxyurea) indicated for Head and Neck Cancer     -   Hydroxyurea indicated for Chronic Myelogenous Leukemia     -   Hydroxyurea indicated for Head and Neck Cancer     -   Ibrance (Palbociclib) indicated for Breast Cancer     -   Ibritumomab Tiuxetan indicated for Non-Hodgkin Lymphoma     -   Ibrutinib indicated for Chronic Lymphocytic Leukemia     -   Ibrutinib indicated for Non-Hodgkin Lymphoma     -   Iclusig (Ponatinib Hydrochloride) indicated for Acute         Lymphoblastic Leukemia     -   Iclusig (Ponatinib Hydrochloride) indicated for Chronic         Myelogenous Leukemia     -   Idamycin PFS (Idarubicin Hydrochloride) indicated for Acute         Myeloid Leukemia     -   Idarubicin Hydrochloride indicated for Acute Myeloid Leukemia     -   Idecabtagene Vicleucel indicated for Multiple Myeloma     -   Idelalisib indicated for Chronic Lymphocytic Leukemia     -   Idelalisib indicated for Non-Hodgkin Lymphoma     -   Idhifa (Enasidenib Mesylate) indicated for Acute Myeloid         Leukemia     -   Ifex (Ifosfamide) indicated for Testicular Cancer     -   Ifosfamide indicated for Testicular Cancer     -   IL-2 (Aldesleukin) indicated for Melanoma     -   IL-2 (Aldesleukin) indicated for Melanoma     -   IL-2 (Aldesleukin) indicated for Renal Cell Cancer     -   Imatinib Mesylate indicated for Acute Lymphoblastic Leukemia     -   Imatinib Mesylate indicated for Chronic Myelogenous Leukemia     -   Imatinib Mesylate indicated for Gastrointestinal Stromal Tumors     -   Imatinib Mesylate indicated for Myeloproliferative Neoplasms     -   Imatinib Mesylate indicated for Soft Tissue Sarcoma     -   Imbruvica (Ibrutinib) indicated for Chronic Lymphocytic Leukemia     -   Imbruvica (Ibrutinib) indicated for Non-Hodgkin Lymphoma     -   Imfinzi (Durvalumab) indicated for Non-Small Cell Lung Cancer     -   Imfinzi (Durvalumab) indicated for Small Cell Lung Cancer     -   Imiquimod indicated for Basal Cell Carcinoma     -   Imlygic (Talimogene Laherparepvec) indicated for Melanoma     -   Imlygic (Talimogene Laherparepvec) indicated for Melanoma     -   Infugem (Gemcitabine Hydrochloride) indicated for Breast Cancer     -   Infugem (Gemcitabine Hydrochloride) indicated for Non-Small Cell         Lung Cancer     -   Infugem (Gemcitabine Hydrochloride) indicated for Ovarian Cancer     -   Infugem (Gemcitabine Hydrochloride) indicated for Pancreatic         Cancer     -   Inlyta (Axitinib) indicated for Renal Cell Cancer     -   Inotuzumab Ozogamicin indicated for Acute Lymphoblastic Leukemia     -   Inqovi (Decitabine and Cedazuridine) indicated for         Myeloproliferative Neoplasms     -   Inrebic (Fedratinib Hydrochloride) indicated for         Myeloproliferative Neoplasms     -   Interleukin-2 (Aldesleukin) indicated for Melanoma     -   Interleukin-2 (Aldesleukin) indicated for Melanoma     -   Interleukin-2 (Aldesleukin) indicated for Renal Cell Cancer     -   Intron A (Recombinant Interferon Alfa-2b) indicated for Hairy         Cell Leukemia     -   Intron A (Recombinant Interferon Alfa-2b) indicated for Kaposi         Sarcoma     -   Intron A (Recombinant Interferon Alfa-2b) indicated for Melanoma     -   Intron A (Recombinant Interferon Alfa-2b) indicated for Melanoma     -   Intron A (Recombinant Interferon Alfa-2b) indicated for         Non-Hodgkin Lymphoma     -   Iobenguane I 131 indicated for Paraganglioma     -   Iobenguane I 131 indicated for Pheochromocytoma     -   Ipilimumab indicated for Colon Cancer     -   Ipilimumab indicated for Malignant Mesothelioma     -   Ipilimumab indicated for Melanoma     -   Ipilimumab indicated for Melanoma     -   Ipilimumab indicated for Non-Small Cell Lung Cancer     -   Ipilimumab indicated for Rectal Cancer     -   Ipilimumab indicated for Renal Cell Cancer     -   Iressa (Gefitinib) indicated for Non-Small Cell Lung Cancer     -   Irinotecan Hydrochloride indicated for Colon Cancer     -   Irinotecan Hydrochloride indicated for Rectal Cancer     -   Irinotecan Hydrochloride Liposome indicated for Pancreatic         Cancer     -   Isatuximab-irfc indicated for Multiple Myeloma     -   Istodax (Romidepsin) indicated for Non-Hodgkin Lymphoma     -   Ivosidenib indicated for Acute Myeloid Leukemia     -   Ixabepilone indicated for Breast Cancer     -   Ixazomib Citrate indicated for Multiple Myeloma     -   Ixempra (Ixabepilone) indicated for Breast Cancer     -   Jakafi (Ruxolitinib Phosphate) indicated for Myeloproliferative         Neoplasms     -   Jelmyto (Mitomycin) indicated for Bladder Cancer     -   Jelmyto (Mitomycin) indicated for Urothelial Cancer     -   Jemperli (Dostarlimab-gxly) indicated for Endometrial Cancer     -   Jevtana (Cabazitaxel) indicated for Prostate Cancer     -   Kadcyla (Ado-Trastuzumab Emtansine) indicated for Breast Cancer     -   Keytruda (Pembrolizumab) indicated for All Solid Tumors     -   Keytruda (Pembrolizumab) indicated for Bladder Cancer     -   Keytruda (Pembrolizumab) indicated for Breast Cancer     -   Keytruda (Pembrolizumab) indicated for Cervical Cancer     -   Keytruda (Pembrolizumab) indicated for Colon Cancer     -   Keytruda (Pembrolizumab) indicated for Cutaneous Squamous Cell         Carcinoma     -   Keytruda (Pembrolizumab) indicated for Endometrial Cancer     -   Keytruda (Pembrolizumab) indicated for Esophageal Cancer     -   Keytruda (Pembrolizumab) indicated for Gastric Cancer     -   Keytruda (Pembrolizumab) indicated for Gastroesophageal Junction         Cancer     -   Keytruda (Pembrolizumab) indicated for Head and Neck Cancer     -   Keytruda (Pembrolizumab) indicated for Hodgkin Lymphoma     -   Keytruda (Pembrolizumab) indicated for Liver Cancer     -   Keytruda (Pembrolizumab) indicated for Melanoma     -   Keytruda (Pembrolizumab) indicated for Melanoma     -   Keytruda (Pembrolizumab) indicated for Merkel Cell Carcinoma     -   Keytruda (Pembrolizumab) indicated for Non-Hodgkin Lymphoma     -   Keytruda (Pembrolizumab) indicated for Non-Small Cell Lung         Cancer     -   Keytruda (Pembrolizumab) indicated for Rectal Cancer     -   Keytruda (Pembrolizumab) indicated for Renal Cell Cancer     -   Kisqali (Ribociclib) indicated for Breast Cancer     -   Kymriah (Tisagenlecleucel) indicated for Acute Lymphoblastic         Leukemia     -   Kymriah (Tisagenlecleucel) indicated for Non-Hodgkin Lymphoma     -   Kyprolis (Carfilzomib) indicated for Multiple Myeloma     -   Lanreotide Acetate indicated for Gastroenteropancreatic         Neuroendocrine Tumors     -   Lapatinib Ditosylate indicated for Breast Cancer     -   Larotrectinib Sulfate indicated for All Solid Tumors     -   Lenalidomide indicated for Multiple Myeloma     -   Lenalidomide indicated for Non-Hodgkin Lymphoma     -   Lenvatinib Mesylate indicated for Endometrial Cancer     -   Lenvatinib Mesylate indicated for Liver Cancer     -   Lenvatinib Mesylate indicated for Renal Cell Cancer     -   Lenvatinib Mesylate indicated for Thyroid Cancer     -   Lenvima (Lenvatinib Mesylate) indicated for Endometrial Cancer     -   Lenvima (Lenvatinib Mesylate) indicated for Liver Cancer     -   Lenvima (Lenvatinib Mesylate) indicated for Renal Cell Cancer     -   Lenvima (Lenvatinib Mesylate) indicated for Thyroid Cancer     -   Letrozole indicated for Breast Cancer     -   Leucovorin Calcium indicated for Colon Cancer     -   Leucovorin Calcium indicated for Rectal Cancer     -   Leukeran (Chlorambucil) indicated for Chronic Lymphocytic         Leukemia     -   Leukeran (Chlorambucil) indicated for Hodgkin Lymphoma     -   Leukeran (Chlorambucil) indicated for Non-Hodgkin Lymphoma     -   Leuprolide Acetate indicated for Prostate Cancer     -   Libtayo (Cemiplimab-rwlc) indicated for Basal Cell Carcinoma     -   Libtayo (Cemiplimab-rwlc) indicated for Cutaneous Squamous Cell         Carcinoma     -   Libtayo (Cemiplimab-rwlc) indicated for Non-Small Cell Lung         Cancer     -   Lisocabtagene Maraleucel indicated for Non-Hodgkin Lymphoma     -   Lomustine indicated for Brain Tumors     -   Lomustine indicated for Hodgkin Lymphoma     -   Loncastuximab Tesirine-lpyl indicated for Non-Hodgkin Lymphoma     -   Lonsurf (Trifluridine and Tipiracil Hydrochloride) indicated for         Colon Cancer     -   Lonsurf (Trifluridine and Tipiracil Hydrochloride) indicated for         Gastric Cancer     -   Lonsurf (Trifluridine and Tipiracil Hydrochloride) indicated for         Gastroesophageal Junction Cancer     -   Lonsurf (Trifluridine and Tipiracil Hydrochloride) indicated for         Rectal Cancer     -   Lorbrena (Lorlatinib) indicated for Non-Small Cell Lung Cancer     -   Lorlatinib indicated for Non-Small Cell Lung Cancer     -   Lumoxiti (Moxetumomab Pasudotox-tdfk) indicated for Hairy Cell         Leukemia     -   Lupron Depot (Leuprolide Acetate) indicated for Prostate Cancer     -   Lurbinectedin indicated for Small Cell Lung Cancer     -   Lynparza (Olaparib) indicated for Breast Cancer     -   Lynparza (Olaparib) indicated for Ovarian Cancer     -   Lynparza (Olaparib) indicated for Pancreatic Cancer     -   Lynparza (Olaparib) indicated for Prostate Cancer     -   Margenza (Margetuximab-cmkb) indicated for Breast Cancer     -   Margetuximab-cmkb indicated for Breast Cancer     -   Marqibo (Vincristine Sulfate Liposome) indicated for Acute         Lymphoblastic Leukemia     -   Matulane (Procarbazine Hydrochloride) indicated for Hodgkin         Lymphoma     -   Megestrol Acetate indicated for Breast Cancer     -   Megestrol Acetate indicated for Endometrial Cancer     -   Mekinist (Trametinib Dimethyl Sulfoxide) indicated for Melanoma     -   Mekinist (Trametinib Dimethyl Sulfoxide) indicated for Melanoma     -   Mekinist (Trametinib Dimethyl Sulfoxide) indicated for Non-Small         Cell Lung Cancer     -   Mekinist (Trametinib Dimethyl Sulfoxide) indicated for Thyroid         Cancer     -   Mektovi (Binimetinib) indicated for Melanoma     -   Melphalan Flufenamide Hydrochloride indicated for Multiple         Myeloma     -   Melphalan Hydrochloride indicated for Multiple Myeloma     -   Melphalan indicated for Multiple Myeloma     -   Melphalan indicated for Ovarian Cancer     -   Mercaptopurine indicated for Acute Lymphoblastic Leukemia     -   Methotrexate Sodium indicated for Acute Lymphoblastic Leukemia     -   Methotrexate Sodium indicated for Bone Cancer     -   Methotrexate Sodium indicated for Breast Cancer     -   Methotrexate Sodium indicated for Gestational Trophoblastic         Disease     -   Methotrexate Sodium indicated for Head and Neck Cancer     -   Methotrexate Sodium indicated for Non-Hodgkin Lymphoma     -   Methotrexate Sodium indicated for Non-Small Cell Lung Cancer     -   Methotrexate Sodium indicated for Small Cell Lung Cancer     -   Midostaurin indicated for Acute Myeloid Leukemia     -   Midostaurin indicated for Mast Cell Leukemia     -   Mitomycin indicated for Bladder Cancer     -   Mitomycin indicated for Gastric Cancer     -   Mitomycin indicated for Pancreatic Cancer     -   Mitomycin indicated for Urothelial Cancer     -   Mitoxantrone Hydrochloride indicated for Acute Myeloid Leukemia     -   Mitoxantrone Hydrochloride indicated for Prostate Cancer     -   Mogamulizumab-kpkc indicated for Non-Hodgkin Lymphoma     -   Monjuvi (Tafasitamab-cxix) indicated for Non-Hodgkin Lymphoma     -   Moxetumomab Pasudotox-tdfk indicated for Hairy Cell Leukemia     -   Mozobil (Plerixafor) indicated for Multiple Myeloma     -   Mozobil (Plerixafor) indicated for Non-Hodgkin Lymphoma     -   Mvasi (Bevacizumab) indicated for Brain Tumors     -   Mvasi (Bevacizumab) indicated for Cervical Cancer     -   Mvasi (Bevacizumab) indicated for Colon Cancer     -   Mvasi (Bevacizumab) indicated for Non-Small Cell Lung Cancer     -   Mvasi (Bevacizumab) indicated for Rectal Cancer     -   Mvasi (Bevacizumab) indicated for Renal Cell Cancer     -   Myleran (Busulfan) indicated for Chronic Myelogenous Leukemia     -   Mylotarg (Gemtuzumab Ozogamicin) indicated for Acute Myeloid         Leukemia     -   Naxitamab-gqgk indicated for Brain Tumors     -   Naxitamab-gqgk indicated for Neuroblastoma     -   Necitumumab indicated for Non-Small Cell Lung Cancer     -   Nelarabine indicated for Acute Lymphoblastic Leukemia     -   Nelarabine indicated for Non-Hodgkin Lymphoma     -   Neratinib Maleate indicated for Breast Cancer     -   Nerlynx (Neratinib Maleate) indicated for Breast Cancer     -   Nexavar (Sorafenib Tosylate) indicated for Liver Cancer     -   Nexavar (Sorafenib Tosylate) indicated for Renal Cell Cancer     -   Nexavar (Sorafenib Tosylate) indicated for Thyroid Cancer     -   Nilandron (Nilutamide) indicated for Prostate Cancer     -   Nilotinib indicated for Chronic Myelogenous Leukemia     -   Nilotinib indicated for Myeloproliferative Neoplasms     -   Nilutamide indicated for Prostate Cancer     -   Ninlaro (Ixazomib Citrate) indicated for Multiple Myeloma     -   Niraparib Tosylate Monohydrate indicated for Ovarian Cancer     -   Nivolumab indicated for Bladder Cancer     -   Nivolumab indicated for Colon Cancer     -   Nivolumab indicated for Esophageal Cancer     -   Nivolumab indicated for Gastric Cancer     -   Nivolumab indicated for Gastroesophageal Junction Cancer     -   Nivolumab indicated for Head and Neck Cancer     -   Nivolumab indicated for Hodgkin Lymphoma     -   Nivolumab indicated for Liver Cancer     -   Nivolumab indicated for Malignant Mesothelioma     -   Nivolumab indicated for Melanoma     -   Nivolumab indicated for Melanoma     -   Nivolumab indicated for Non-Small Cell Lung Cancer     -   Nivolumab indicated for Rectal Cancer     -   Nivolumab indicated for Renal Cell Cancer     -   Nivolumab indicated for Small Cell Lung Cancer     -   Nubeqa (Darolutamide) indicated for Prostate Cancer     -   Obinutuzumab indicated for Chronic Lymphocytic Leukemia     -   Obinutuzumab indicated for Non-Hodgkin Lymphoma     -   Odomzo (Sonidegib) indicated for Basal Cell Carcinoma     -   Ofatumumab indicated for Chronic Lymphocytic Leukemia     -   Olaparib indicated for Breast Cancer     -   Olaparib indicated for Ovarian Cancer     -   Olaparib indicated for Pancreatic Cancer     -   Olaparib indicated for Prostate Cancer     -   Omacetaxine Mepesuccinate indicated for Chronic Myelogenous         Leukemia     -   Oncaspar (Pegaspargase) indicated for Acute Lymphoblastic         Leukemia     -   Onivyde (Irinotecan Hydrochloride Liposome) indicated for         Pancreatic Cancer     -   Ontak (Denileukin Diftitox) indicated for Non-Hodgkin Lymphoma     -   Onureg (Azacitidine) indicated for Acute Myeloid Leukemia     -   Opdivo (Nivolumab) indicated for Bladder Cancer     -   Opdivo (Nivolumab) indicated for Colon Cancer     -   Opdivo (Nivolumab) indicated for Esophageal Cancer     -   Opdivo (Nivolumab) indicated for Gastric Cancer     -   Opdivo (Nivolumab) indicated for Gastroesophageal Junction         Cancer     -   Opdivo (Nivolumab) indicated for Head and Neck Cancer     -   Opdivo (Nivolumab) indicated for Hodgkin Lymphoma     -   Opdivo (Nivolumab) indicated for Liver Cancer     -   Opdivo (Nivolumab) indicated for Malignant Mesothelioma     -   Opdivo (Nivolumab) indicated for Melanoma     -   Opdivo (Nivolumab) indicated for Melanoma     -   Opdivo (Nivolumab) indicated for Non-Small Cell Lung Cancer     -   Opdivo (Nivolumab) indicated for Rectal Cancer     -   Opdivo (Nivolumab) indicated for Renal Cell Cancer     -   Opdivo (Nivolumab) indicated for Small Cell Lung Cancer     -   Orgovyx (Relugolix) indicated for Prostate Cancer     -   Osimertinib Mesylate indicated for Non-Small Cell Lung Cancer     -   Oxaliplatin indicated for Colon Cancer     -   Oxaliplatin indicated for Rectal Cancer     -   Paclitaxel Albumin-stabilized Nanoparticle Formulation indicated         for Breast Cancer     -   Paclitaxel Albumin-stabilized Nanoparticle Formulation indicated         for Non-Small Cell Lung Cancer     -   Paclitaxel Albumin-stabilized Nanoparticle Formulation indicated         for Pancreatic Cancer     -   Paclitaxel indicated for Breast Cancer     -   Paclitaxel indicated for Kaposi Sarcoma     -   Paclitaxel indicated for Non-Small Cell Lung Cancer     -   Paclitaxel indicated for Ovarian Cancer     -   Padcev (Enfortumab Vedotin-ejfv) indicated for Bladder Cancer     -   Palbociclib indicated for Breast Cancer     -   Pamidronate Disodium indicated for Breast Cancer     -   Pamidronate Disodium indicated for Multiple Myeloma     -   Panitumumab indicated for Colon Cancer     -   Panitumumab indicated for Rectal Cancer     -   Panobinostat Lactate indicated for Multiple Myeloma     -   Paraplat (Carboplatin) indicated for Non-Small Cell Lung Cancer     -   Paraplatin (Carboplatin) indicated for Non-Small Cell Lung         Cancer     -   Pazopanib Hydrochloride indicated for Renal Cell Cancer     -   Pazopanib Hydrochloride indicated for Soft Tissue Sarcoma     -   PEG-Intron (Peginterferon Alfa-2b) indicated for Melanoma     -   Pegaspargase indicated for Acute Lymphoblastic Leukemia     -   Peginterferon Alfa-2b indicated for Melanoma     -   Peginterferon Alfa-2b indicated for Melanoma     -   Pemazyre (Pemigatinib) indicated for Liver Cancer     -   Pembrolizumab indicated for All Solid Tumors     -   Pembrolizumab indicated for Bladder Cancer     -   Pembrolizumab indicated for Breast Cancer     -   Pembrolizumab indicated for Cervical Cancer     -   Pembrolizumab indicated for Colon Cancer     -   Pembrolizumab indicated for Cutaneous Squamous Cell Carcinoma     -   Pembrolizumab indicated for Endometrial Cancer     -   Pembrolizumab indicated for Esophageal Cancer     -   Pembrolizumab indicated for Gastric Cancer     -   Pembrolizumab indicated for Gastroesophageal Junction Cancer     -   Pembrolizumab indicated for Head and Neck Cancer     -   Pembrolizumab indicated for Hodgkin Lymphoma     -   Pembrolizumab indicated for Liver Cancer     -   Pembrolizumab indicated for Melanoma     -   Pembrolizumab indicated for Melanoma     -   Pembrolizumab indicated for Merkel Cell Carcinoma     -   Pembrolizumab indicated for Non-Hodgkin Lymphoma     -   Pembrolizumab indicated for Non-Small Cell Lung Cancer     -   Pembrolizumab indicated for Rectal Cancer     -   Pembrolizumab indicated for Renal Cell Cancer     -   Pemetrexed Disodium indicated for Malignant Mesothelioma     -   Pemetrexed Disodium indicated for Non-Small Cell Lung Cancer     -   Pemigatinib indicated for Liver Cancer     -   Peptaxto (Melphalan Flufenamide Hydrochloride) indicated for         Multiple Myeloma     -   Perj eta (Pertuzumab) indicated for Breast Cancer     -   Pertuzumab indicated for Breast Cancer     -   Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf indicated for         Breast Cancer     -   Phesgo (Pertuzumab, Trastuzumab, and Hyaluronidase-zzxf)         indicated for Breast Cancer     -   Piqray (Alpelisib) indicated for Breast Cancer     -   Plerixafor indicated for Multiple Myeloma     -   Plerixafor indicated for Non-Hodgkin Lymphoma     -   Polatuzumab Vedotin-piiq indicated for Non-Hodgkin Lymphoma     -   Polivy (Polatuzumab Vedotin-piiq) indicated for Non-Hodgkin         Lymphoma     -   Pomalidomide indicated for Kaposi Sarcoma     -   Pomalidomide indicated for Multiple Myeloma     -   Pomalyst (Pomalidomide) indicated for Kaposi Sarcoma     -   Pomalyst (Pomalidomide) indicated for Multiple Myeloma     -   Ponatinib Hydrochloride indicated for Acute Lymphoblastic         Leukemia     -   Ponatinib Hydrochloride indicated for Chronic Myelogenous         Leukemia     -   Portrazza (Necitumumab) indicated for Non-Small Cell Lung Cancer     -   Poteligeo (Mogamulizumab-kpkc) indicated for Non-Hodgkin         Lymphoma     -   Pralatrexate indicated for Non-Hodgkin Lymphoma     -   Pralsetinib indicated for Non-Small Cell Lung Cancer     -   Pralsetinib indicated for Thyroid Cancer     -   Prednisone indicated for Acute Lymphoblastic Leukemia     -   Prednisone indicated for Acute Myeloid Leukemia     -   Prednisone indicated for Chronic Lymphocytic Leukemia     -   Prednisone indicated for Hodgkin Lymphoma     -   Prednisone indicated for Non-Hodgkin Lymphoma     -   Procarbazine Hydrochloride indicated for Hodgkin Lymphoma     -   Proleukin (Aldesleukin) indicated for Melanoma     -   Proleukin (Aldesleukin) indicated for Melanoma     -   Proleukin (Aldesleukin) indicated for Renal Cell Cancer     -   Propranolol Hydrochloride indicated for Pheochromocytoma     -   Provenge (Sipuleucel-T) indicated for Prostate Cancer     -   Purinethol (Mercaptopurine) indicated for Acute Lymphoblastic         Leukemia     -   Purixan (Mercaptopurine) indicated for Acute Lymphoblastic         Leukemia     -   Qinlock (Ripretinib) indicated for Gastrointestinal Stromal         Tumors     -   Radium 223 Dichloride indicated for Prostate Cancer     -   Ramucirumab indicated for Colon Cancer     -   Ramucirumab indicated for Gastric Cancer     -   Ramucirumab indicated for Gastroesophageal Junction Cancer     -   Ramucirumab indicated for Liver Cancer     -   Ramucirumab indicated for Non-Small Cell Lung Cancer     -   Ramucirumab indicated for Rectal Cancer     -   Recombinant Interferon Alfa-2b indicated for Hairy Cell Leukemia     -   Recombinant Interferon Alfa-2b indicated for Kaposi Sarcoma     -   Recombinant Interferon Alfa-2b indicated for Melanoma     -   Recombinant Interferon Alfa-2b indicated for Melanoma     -   Recombinant Interferon Alfa-2b indicated for Non-Hodgkin         Lymphoma     -   Regorafenib indicated for Colon Cancer     -   Regorafenib indicated for Gastrointestinal Stromal Tumors     -   Regorafenib indicated for Liver Cancer     -   Regorafenib indicated for Rectal Cancer     -   Relugolix indicated for Prostate Cancer     -   Retevmo (Selpercatinib) indicated for Non-Small Cell Lung Cancer     -   Retevmo (Selpercatinib) indicated for Thyroid Cancer     -   Revlimid (Lenalidomide) indicated for Multiple Myeloma     -   Revlimid (Lenalidomide) indicated for Non-Hodgkin Lymphoma     -   Ribociclib indicated for Breast Cancer     -   Ripretinib indicated for Gastrointestinal Stromal Tumors     -   Rituxan (Rituximab) indicated for Chronic Lymphocytic Leukemia     -   Rituxan (Rituximab) indicated for Non-Hodgkin Lymphoma     -   Rituxan Hycela (Rituximab and Hyaluronidase Human) indicated for         Chronic Lymphocytic Leukemia     -   Rituxan Hycela (Rituximab and Hyaluronidase Human) indicated for         Non-Hodgkin Lymphoma     -   Rituximab and Hyaluronidase Human indicated for Chronic         Lymphocytic Leukemia     -   Rituximab and Hyaluronidase Human indicated for Non-Hodgkin         Lymphoma     -   Rituximab indicated for Chronic Lymphocytic Leukemia     -   Rituximab indicated for Non-Hodgkin Lymphoma     -   Romidepsin indicated for Non-Hodgkin Lymphoma     -   Rozlytrek (Entrectinib) indicated for All Solid Tumors     -   Rozlytrek (Entrectinib) indicated for Non-Small Cell Lung Cancer     -   Rubidomycin (Daunorubicin Hydrochloride) indicated for Acute         Lymphoblastic Leukemia     -   Rubidomycin (Daunorubicin Hydrochloride) indicated for Acute         Myeloid Leukemia     -   Rubidomycin (Daunorubicin Hydrochloride) indicated for         Myeloproliferative Neoplasms     -   Rubraca (Rucaparib Camsylate) indicated for Ovarian Cancer     -   Rubraca (Rucaparib Camsylate) indicated for Prostate Cancer     -   Rucaparib Camsylate indicated for Ovarian Cancer     -   Rucaparib Camsylate indicated for Prostate Cancer     -   Ruxolitinib Phosphate indicated for Myeloproliferative Neoplasms     -   Rydapt (Midostaurin) indicated for Acute Myeloid Leukemia     -   Rydapt (Midostaurin) indicated for Mast Cell Leukemia     -   Sacituzumab Govitecan-hziy indicated for Bladder Cancer     -   Sacituzumab Govitecan-hziy indicated for Breast Cancer     -   Sarclisa (Isatuximab-irfc) indicated for Multiple Myeloma     -   Selinexor indicated for Multiple Myeloma     -   Selinexor indicated for Non-Hodgkin Lymphoma     -   Selpercatinib indicated for Non-Small Cell Lung Cancer     -   Selpercatinib indicated for Thyroid Cancer     -   Siltuximab indicated for Multicentric Castleman Disease     -   Sipuleucel-T indicated for Prostate Cancer     -   Soltamox (Tamoxifen Citrate) indicated for Breast Cancer     -   Somatuline Depot (Lanreotide Acetate) indicated for         Gastroenteropancreatic Neuroendocrine Tumors     -   Sonidegib indicated for Basal Cell Carcinoma     -   Sorafenib Tosylate indicated for Liver Cancer     -   Sorafenib Tosylate indicated for Renal Cell Cancer     -   Sorafenib Tosylate indicated for Thyroid Cancer     -   Sprycel (Dasatinib) indicated for Acute Lymphoblastic Leukemia     -   Sprycel (Dasatinib) indicated for Chronic Myelogenous Leukemia     -   Sprycel (Dasatinib) indicated for Myeloproliferative Neoplasms     -   Stivarga (Regorafenib) indicated for Colon Cancer     -   Stivarga (Regorafenib) indicated for Gastrointestinal Stromal         Tumors     -   Stivarga (Regorafenib) indicated for Liver Cancer     -   Stivarga (Regorafenib) indicated for Rectal Cancer     -   Sunitinib Malate indicated for Gastrointestinal Stromal Tumors     -   Sunitinib Malate indicated for Pancreatic Cancer     -   Sunitinib Malate indicated for Renal Cell Cancer     -   Sutent (Sunitinib Malate) indicated for Gastrointestinal Stromal         Tumors     -   Sutent (Sunitinib Malate) indicated for Pancreatic Cancer     -   Sutent (Sunitinib Malate) indicated for Renal Cell Cancer     -   Sylatron (Peginterferon Alfa-2b) indicated for Melanoma     -   Sylatron (Peginterferon Alfa-2b) indicated for Melanoma     -   Sylvant (Siltuximab) indicated for Multicentric Castleman         Disease     -   Synribo (Omacetaxine Mepesuccinate) indicated for Chronic         Myelogenous Leukemia     -   Tabloid (Thioguanine) indicated for Acute Myeloid Leukemia     -   Tabrecta (Capmatinib Hydrochloride) indicated for Non-Small Cell         Lung Cancer     -   Tafasitamab-cxix indicated for Non-Hodgkin Lymphoma     -   Tafinlar (Dabrafenib Mesylate) indicated for Melanoma     -   Tafinlar (Dabrafenib Mesylate) indicated for Non-Small Cell Lung         Cancer     -   Tafinlar (Dabrafenib Mesylate) indicated for Thyroid Cancer     -   Tafinlar (Dabrafenib) indicated for Melanoma     -   Tagraxofusp-erzs indicated for Blastic Plasmacytoid Dendritic         Cell Neoplasm     -   Tagrisso (Osimertinib Mesylate) indicated for Non-Small Cell         Lung Cancer     -   Talazoparib Tosylate indicated for Breast Cancer     -   Talimogene Laherparepvec indicated for Melanoma     -   Talimogene Laherparepvec indicated for Melanoma     -   Talzenna (Talazoparib Tosylate) indicated for Breast Cancer     -   Tamoxifen Citrate indicated for Breast Cancer     -   Tarabine PFS (Cytarabine) indicated for Myeloproliferative         Neoplasms     -   Tarceva (Erlotinib Hydrochloride) indicated for Non-Small Cell         Lung Cancer     -   Tarceva (Erlotinib Hydrochloride) indicated for Pancreatic         Cancer     -   Tasigna (Nilotinib) indicated for Chronic Myelogenous Leukemia     -   Tasigna (Nilotinib) indicated for Myeloproliferative Neoplasms     -   Taxotere (Docetaxel) indicated for Breast Cancer     -   Taxotere (Docetaxel) indicated for Gastric Cancer     -   Taxotere (Docetaxel) indicated for Gastroesophageal Junction         Cancer     -   Taxotere (Docetaxel) indicated for Head and Neck Cancer     -   Taxotere (Docetaxel) indicated for Non-Small Cell Lung Cancer     -   Taxotere (Docetaxel) indicated for Prostate Cancer     -   Tazemetostat Hydrobromide indicated for Non-Hodgkin Lymphoma     -   Tazemetostat Hydrobromide indicated for Soft Tissue Sarcoma     -   Tazverik (Tazemetostat Hydrobromide) indicated for Non-Hodgkin         Lymphoma     -   Tazverik (Tazemetostat Hydrobromide) indicated for Soft Tissue         Sarcoma     -   Tecartus (Brexucabtagene Autoleucel) indicated for Non-Hodgkin         Lymphoma     -   Tecentriq (Atezolizumab) indicated for Bladder Cancer     -   Tecentriq (Atezolizumab) indicated for Breast Cancer     -   Tecentriq (Atezolizumab) indicated for Liver Cancer     -   Tecentriq (Atezolizumab) indicated for Non-Small Cell Lung         Cancer     -   Tecentriq (Atezolizumab) indicated for Small Cell Lung Cancer     -   Temodar (Temozolomide) indicated for Brain Tumors     -   Temozolomide indicated for Brain Tumors     -   Temsirolimus indicated for Renal Cell Cancer     -   Tepadina (Thiotepa) indicated for Bladder Cancer     -   Tepadina (Thiotepa) indicated for Breast Cancer     -   Tepadina (Thiotepa) indicated for Ovarian Cancer     -   Tepmetko (Tepotinib Hydrochloride) indicated for Non-Small Cell         Lung Cancer     -   Tepotinib Hydrochloride indicated for Non-Small Cell Lung Cancer     -   Thalidomide indicated for Multiple Myeloma     -   Thalomid (Thalidomide) indicated for Multiple Myeloma     -   Thioguanine indicated for Acute Myeloid Leukemia     -   Thiotepa indicated for Bladder Cancer     -   Thiotepa indicated for Breast Cancer     -   Thiotepa indicated for Ovarian Cancer     -   Tibsovo (Ivosidenib) indicated for Acute Myeloid Leukemia     -   Tisagenlecleucel indicated for Acute Lymphoblastic Leukemia     -   Tisagenlecleucel indicated for Non-Hodgkin Lymphoma     -   Tivozanib Hydrochloride indicated for Renal Cell Cancer     -   Topotecan Hydrochloride indicated for Cervical Cancer     -   Topotecan Hydrochloride indicated for Ovarian Cancer     -   Topotecan Hydrochloride indicated for Small Cell Lung Cancer     -   Toremifene indicated for Breast Cancer     -   Torisel (Temsirolimus) indicated for Renal Cell Cancer     -   Trabectedin indicated for Soft Tissue Sarcoma     -   Trametinib Dimethyl Sulfoxide indicated for Melanoma     -   Trametinib Dimethyl Sulfoxide indicated for Melanoma     -   Trametinib Dimethyl Sulfoxide indicated for Non-Small Cell Lung         Cancer     -   Trametinib Dimethyl Sulfoxide indicated for Thyroid Cancer     -   Trastuzumab and Hyaluronidase-oysk indicated for Breast Cancer     -   Trastuzumab indicated for Breast Cancer     -   Trastuzumab indicated for Gastric Cancer     -   Trastuzumab indicated for Gastroesophageal Junction Cancer     -   Treanda (Bendamustine Hydrochloride) indicated for Chronic         Lymphocytic Leukemia     -   Treanda (Bendamustine Hydrochloride) indicated for Non-Hodgkin         Lymphoma     -   Trexall (Methotrexate Sodium) indicated for Acute Lymphoblastic         Leukemia     -   Trexall (Methotrexate Sodium) indicated for Bone Cancer     -   Trexall (Methotrexate Sodium) indicated for Breast Cancer     -   Trexall (Methotrexate Sodium) indicated for Gestational         Trophoblastic Disease     -   Trexall (Methotrexate Sodium) indicated for Head and Neck Cancer     -   Trexall (Methotrexate Sodium) indicated for Non-Hodgkin Lymphoma     -   Trexall (Methotrexate Sodium) indicated for Non-Small Cell Lung         Cancer     -   Trexall (Methotrexate Sodium) indicated for Small Cell Lung         Cancer     -   Trifluridine and Tipiracil Hydrochloride indicated for Colon         Cancer     -   Trifluridine and Tipiracil Hydrochloride indicated for Gastric         Cancer     -   Trifluridine and Tipiracil Hydrochloride indicated for         Gastroesophageal Junction Cancer     -   Trifluridine and Tipiracil Hydrochloride indicated for Rectal         Cancer     -   Trisenox (Arsenic Trioxide) indicated for Acute Myeloid Leukemia     -   Trisenox (Arsenic Trioxide) indicated for Myeloproliferative         Neoplasms     -   Trodelvy (Sacituzumab Govitecan-hziy) indicated for Bladder         Cancer     -   Trodelvy (Sacituzumab Govitecan-hziy) indicated for Breast         Cancer     -   Truxima (Rituximab) indicated for Chronic Lymphocytic Leukemia     -   Truxima (Rituximab) indicated for Non-Hodgkin Lymphoma     -   Tucatinib indicated for Breast Cancer     -   Tukysa (Tucatinib) indicated for Breast Cancer     -   Tykerb (Lapatinib Ditosylate) indicated for Breast Cancer     -   Ukoniq (Umbralisib Tosylate) indicated for Non-Hodgkin Lymphoma     -   Umbralisib Tosylate indicated for Non-Hodgkin Lymphoma     -   Unituxin (Dinutuximab) indicated for Neuroblastoma     -   Valrubicin indicated for Bladder Cancer     -   Valstar (Valrubicin) indicated for Bladder Cancer     -   Vandetanib indicated for Thyroid Cancer     -   Vectibix (Panitumumab) indicated for Colon Cancer     -   Vectibix (Panitumumab) indicated for Rectal Cancer     -   Velcade (Bortezomib) indicated for Multiple Myeloma     -   Velcade (Bortezomib) indicated for Non-Hodgkin Lymphoma     -   Vemurafenib indicated for Melanoma     -   Vemurafenib indicated for Melanoma     -   Venclexta (Venetoclax) indicated for Acute Myeloid Leukemia     -   Venclexta (Venetoclax) indicated for Chronic Lymphocytic         Leukemia     -   Venclexta (Venetoclax) indicated for Non-Hodgkin Lymphoma     -   Venetoclax indicated for Acute Myeloid Leukemia     -   Venetoclax indicated for Chronic Lymphocytic Leukemia     -   Venetoclax indicated for Non-Hodgkin Lymphoma     -   Verzenio (Abemaciclib) indicated for Breast Cancer     -   Vidaza (Azacitidine) indicated for Myeloproliferative Neoplasms     -   Vinblastine Sulfate indicated for Breast Cancer     -   Vinblastine Sulfate indicated for Gestational Trophoblastic         Disease     -   Vinblastine Sulfate indicated for Hodgkin Lymphoma     -   Vinblastine Sulfate indicated for Kaposi Sarcoma     -   Vinblastine Sulfate indicated for Non-Hodgkin Lymphoma     -   Vinblastine Sulfate indicated for Testicular Cancer     -   Vincristine Sulfate indicated for Acute Lymphoblastic Leukemia     -   Vincristine Sulfate indicated for Acute Myeloid Leukemia     -   Vincristine Sulfate indicated for Childhood Kidney Cancers     -   Vincristine Sulfate indicated for Hodgkin Lymphoma     -   Vincristine Sulfate indicated for Neuroblastoma     -   Vincristine Sulfate indicated for Non-Hodgkin Lymphoma     -   Vincristine Sulfate indicated for Rhabdomyosarcoma     -   Vincristine Sulfate Liposome indicated for Acute Lymphoblastic         Leukemia     -   Vinorelbine Tartrate indicated for Non-Small Cell Lung Cancer     -   Vismodegib indicated for Basal Cell Carcinoma     -   Vitrakvi (Larotrectinib Sulfate) indicated for All Solid Tumors     -   Vizimpro (Dacomitinib) indicated for Non-Small Cell Lung Cancer     -   Vorinostat indicated for Non-Hodgkin Lymphoma     -   Votrient (Pazopanib Hydrochloride) indicated for Renal Cell         Cancer     -   Votrient (Pazopanib Hydrochloride) indicated for Soft Tissue         Sarcoma     -   Vyxeos (Daunorubicin Hydrochloride and Cytarabine Liposome)         indicated for Acute Myeloid Leukemia     -   Xalkori (Crizotinib) indicated for Non-Hodgkin Lymphoma     -   Xalkori (Crizotinib) indicated for Non-Small Cell Lung Cancer     -   Xeloda (Capecitabine) indicated for Breast Cancer     -   Xeloda (Capecitabine) indicated for Colon Cancer     -   Xeloda (Capecitabine) indicated for Rectal Cancer     -   Xgeva (Denosumab) indicated for Bone Cancer     -   Xofigo (Radium 223 Dichloride) indicated for Prostate Cancer     -   Xospata (Gilteritinib Fumarate) indicated for Acute Myeloid         Leukemia     -   Xpovio (Selinexor) indicated for Multiple Myeloma     -   Xpovio (Selinexor) indicated for Non-Hodgkin Lymphoma     -   Xtandi (Enzalutamide) indicated for Prostate Cancer     -   Yervoy (Ipilimumab) indicated for Colon Cancer     -   Yervoy (Ipilimumab) indicated for Malignant Mesothelioma     -   Yervoy (Ipilimumab) indicated for Melanoma     -   Yervoy (Ipilimumab) indicated for Melanoma     -   Yervoy (Ipilimumab) indicated for Non-Small Cell Lung Cancer     -   Yervoy (Ipilimumab) indicated for Rectal Cancer     -   Yervoy (Ipilimumab) indicated for Renal Cell Cancer     -   Yescarta (Axicabtagene Ciloleucel) indicated for Non-Hodgkin         Lymphoma     -   Yondelis (Trabectedin) indicated for Soft Tissue Sarcoma     -   Yonsa (Abiraterone Acetate) indicated for Prostate Cancer     -   Zaltrap (Ziv-Aflibercept) indicated for Colon Cancer     -   Zaltrap (Ziv-Aflibercept) indicated for Rectal Cancer     -   Zanubrutinib indicated for Non-Hodgkin Lymphoma     -   Zejula (Niraparib Tosylate Monohydrate) indicated for Ovarian         Cancer     -   Zelboraf (Vemurafenib) indicated for Melanoma     -   Zelboraf (Vemurafenib) indicated for Melanoma     -   Zepzelca (Lurbinectedin) indicated for Small Cell Lung Cancer     -   Zevalin (Ibritumomab Tiuxetan) indicated for Non-Hodgkin         Lymphoma     -   Zirabev (Bevacizumab) indicated for Brain Tumors     -   Zirabev (Bevacizumab) indicated for Cervical Cancer     -   Zirabev (Bevacizumab) indicated for Colon Cancer     -   Zirabev (Bevacizumab) indicated for Non-Small Cell Lung Cancer     -   Zirabev (Bevacizumab) indicated for Rectal Cancer     -   Zirabev (Bevacizumab) indicated for Renal Cell Cancer     -   Ziv-Aflibercept indicated for Colon Cancer     -   Ziv-Aflibercept indicated for Rectal Cancer     -   Zoladex (Goserelin Acetate) indicated for Breast Cancer     -   Zoladex (Goserelin Acetate) indicated for Prostate Cancer     -   Zoledronic Acid indicated for Bone Cancer     -   Zoledronic Acid indicated for Multiple Myeloma     -   Zolinza (Vorinostat) indicated for Non-Hodgkin Lymphoma     -   Zometa (Zoledronic Acid) indicated for Multiple Myeloma     -   Zometa indicated for Bone Cancer     -   Zydelig (Idelalisib) indicated for Chronic Lymphocytic Leukemia     -   Zydelig (Idelalisib) indicated for Non-Hodgkin Lymphoma     -   Zykadia (Ceritinib) indicated for Non-Small Cell Lung Cancer     -   Zynlonta (Loncastuximab Tesirine-lpyl) indicated for Non-Hodgkin         Lymphoma     -   Zytiga (Abiraterone Acetate) indicated for Prostate Cancer         Side effects associated with combination cancer treatments:     -   ABVD (Adriamycin, Bleomycin, Vinblasine, Dacarbazine indicated         for Hodgkin Lymphoma     -   ABVE (Adriamycin, Bleomycin, Vincristine Sulfate, Etoposide         Phosphate) indicated for Hodgkin Lymphoma     -   ABVE-PC (Adriamycin, Bleomycin, Vincristine Sulfate, Etoposide         Phosphate, Prednisone, Cyclophophamide) indicated for Hodgkin         Lymphoma     -   AC (Adriamycin, Cyclophophamide) indicated for Breast Cancer     -   AC-T (Adriamycin, Cyclophophamide, Taxol) indicated for Breast         Cancer     -   ADE (Cytarabine, Daunorubicine Hydrochloride, Etoposide         Phosphate) indicated for Acute Myeloid Leukemia     -   ADE (Cytarabine, Daunorubicine Hydrochloride, Etoposide         Phosphate) indicated for Myeloproliferative Neoplasms     -   BEACOPP (Bleomycin, Etoposide, Adriamycin, Cyclophosphamide,         Oncovin, Procarbazine, Prednisone) indicated for Hodgkin         Lymphoma     -   BEP (Bleomycin, Etoposide, Cisplatin) indicated for Ovarian         Cancer     -   BEP (Bleomycin, Etoposide, Cisplatin) indicated for Testicular         Cancer     -   BuMel (Busulfan, Melphalan Hysrochloride) indicated for         Neuroblastoma     -   CAF (Cyclophosphamide, Adriamycin, Fluorouracil) indicated for         Breast Cancer     -   CAPDX (Capecitabine, Oxaliplatin) indicated for Colon Cancer     -   CAPDX (Capecitabine, Oxaliplatin) indicated for Rectal Cancer     -   CARBOPLATIN-TAXOL (Carboplatin, Paclitaxel) indicated for         Non-Small Cell Lung Cancer     -   CARBOPLATIN-TAXOL (Carboplatin, Paclitaxel) indicated for         Ovarian Cancer     -   CEM (Carboplatin, Etoposide Phosphate, Melphalan Hydrochloride)         indicated for Neuroblastoma     -   CEV (Carboplatin, Etoposide Phosphate, Vincristine Sulfate)         indicated for Retinoblastoma     -   CHLORAMBUCIL-PREDNISONE indicated for Chronic Lymphocytic         Leukemia     -   CHOP (Cyclophosphamide, Doxorubicin Hydrochloride, Vincristine         Sulfate (Onvocin), Prednisone) indicated for Non-Hodgkin         Lymphoma     -   CMF (Cyclophosphamide, Methotrexate, Fluorouracil) indicated for         Breast Cancer     -   COPDAC (Cyclophosphamide, Vincristine Sulfate (Oncovin),         Prednisone, Dacarbazine) indicated for Hodgkin Lymphoma     -   COPP (Cyclophosphamide, Vincristine Sulfate (Oncovin),         Procarbazine Hydrochloride, Prednisone) indicated for Hodgkin         Lymphoma     -   COPP (Cyclophosphamide, Vincristine Sulfate (Oncovin),         Procarbazine Hydrochloride, Prednisone) indicated for         Non-Hodgkin Lymphoma     -   COPP-ABV ((Cyclophosphamide, Vincristine Sulfate (Oncovin),         Procarbazine Hydrochloride, Prednisone, Adriamycin, Bleomycin,         Vinblastine Sulfate) indicated for Hodgkin Lymphoma     -   CVP (Cyclophosphamide, Vincristine Sulfate, Prednisone)         indicated for Chronic Lymphocytic Leukemia     -   CVP (Cyclophosphamide, Vincristine Sulfate, Prednisone)         indicated for Non-Hodgkin Lymphoma     -   EPOCH (Etoposide Phosphate, Prednisone, Vincristine Sulfate         (Oncovin), Cyclophosphamide, Doxorubicin Hydrochloride         (Hydroxydaunomycin) indicated for Non-Hodgkin Lymphoma     -   FEC (Fluorouracil, Epirubicin Hydrochloride, Cyclophosphamide)         indicated for Breast Cancer     -   FOLFIRI (Leucovorin Calcium (Folinic Acid), Fluorouracil,         Irinotecan Hydrochloride) indicated for Colon Cancer     -   FOLFIRI (Leucovorin Calcium (Folinic Acid), Fluorouracil,         Irinotecan Hydrochloride) indicated for Rectal Cancer     -   FOLFIRI-BEVACIZUMAB (Leucovorin Calcium (Folinic Acid),         Fluorouracil, Irinotecan Hydrochloride, Bevacizumab) indicated         for Colon Cancer     -   FOLFIRI-BEVACIZUMAB (Leucovorin Calcium (Folinic Acid),         Fluorouracil, Irinotecan Hydrochloride, Bevacizumab) indicated         for Rectal Cancer     -   FOLFIRI-CETUXIMAB (Leucovorin Calcium (Folinic Acid),         Fluorouracil, Irinotecan Hydrochloride, Cetuximab) indicated for         Colon Cancer     -   FOLFIRI-CETUXIMAB (Leucovorin Calcium (Folinic Acid),         Fluorouracil, Irinotecan Hydrochloride, Cetuximab) indicated for         Rectal Cancer     -   FOLFIRINOX (Leucovorin Calcium (Folinic Acid), Fluorouracil,         Irinotecan Hydrochloride, Oxaliplatin) indicated for Pancreatic         Cancer     -   FOLFOX (Leucovorin Calcium (Folinic Acid), Fluorouracil,         Oxaliplatin) indicated for Colon Cancer     -   FOLFOX Leucovorin Calcium (Folinic Acid), Fluorouracil,         Oxaliplatin) indicated for Rectal Cancer     -   FU-LV (Fluorouracil, Leucovorin Calcium) indicated for Colon         Cancer     -   FU-LV (Fluorouracil, Leucovorin Calcium) indicated for         Esophageal Cancer     -   FU-LV (Fluorouracil, Leucovorin Calcium) indicated for Gastric         Cancer     -   FU-LV (Fluorouracil, Leucovorin Calcium) indicated for Rectal         Cancer     -   GEMCITABINE-CISPLATIN indicated for Bladder Cancer     -   Gemcitabine-Cisplatin indicated for Cervical Cancer     -   GEMCITABINE-CISPLATIN indicated for Malignant Mesothelioma     -   GEMCITABINE-CISPLATIN indicated for Non-Small Cell Lung Cancer     -   GEMCITABINE-CISPLATIN indicated for Ovarian Cancer     -   GEMCITABINE-CISPLATIN indicated for Pancreatic Cancer     -   GEMCITABINE-OXALIPLATIN indicated for Pancreatic Cancer     -   Hyper-CVAD (Cyclophosphamide, Vincristine Sulfate, Doxorubicin         Hydrochloride (Adriamycin) Dexamethasone) indicated for Acute         Lymphoblastic Leukemia     -   Hyper-CVAD (Cyclophosphamide, Vincristine Sulfate, Doxorubicin         Hydrochloride (Adriamycin) Dexamethasone) indicated for         Non-Hodgkin Lymphoma     -   ICE (Ifosfamide, Carboplatin, Etoposide Phosphate) indicated for         Hodgkin Lymphoma     -   ICE (Ifosfamide, Carboplatin, Etoposide Phosphate) indicated for         Non-Hodgkin Lymphoma     -   JEB (Carboplatin (JM8), Etoposide Phosphate, Bleomycin)         indicated for Ovarian Cancer     -   JEB (Carboplatin (JM8), Etoposide Phosphate, Bleomycin)         indicated for Testicular Cancer     -   MOPP (Mechlorethamine Hydrochloride, Vincristine Sulfate         (Oncovin), Procarbazine Hydrochloride, Prednisone) indicated for         Hodgkin Lymphoma     -   MVAC (Methotrexate, Vinblastine Sulfate, Doxorubicin         Hydrochloride (Adriamycin), Cisplatin) indicated for Bladder         Cancer     -   OEPA (Vincristine Sulfate (Oncovin), Etoposide Phosphate,         Prednisone, Doxorubicin Hydrochloride (Adriamycin)) indicated         for Hodgkin Lymphoma     -   OFF (Oxaliplatin, Fluorouracil, Leucovorin Calcium (Folinic         Acid)) indicated for Pancreatic Cancer     -   OPPA (Vincristine Sulfate (Oncovin), Procarbazine Hydrochloride,         Prednisone, Doxorubicin Hydrochloride (Adriamycin)) indicated         for Hodgkin Lymphoma     -   PAD (Bortezomib (PS-341), Doxorubicin Hydrochloride         (Adriamycin), Dexamethasone) indicated for Multiple Myeloma     -   PCV (Procarbazine Hydrochloride, Lomustine (CCNU), Vincristine         Sulfate) indicated for Brain Tumors     -   PEB (Cisplatin (Platinol), Etoposide Phosphate, Bleomycin)         indicated for Ovarian Cancer     -   PEB (Cisplatin (Platinol), Etoposide Phosphate, Bleomycin)         indicated for Testicular Cancer     -   R-CHOP (Rituximab, Cyclophosphamide, Doxorubicin Hydrochloride,         Vincristine Sulfate (Onvocin), Prednisone) indicated for         Non-Hodgkin Lymphoma     -   R-CVP (Rituximab, Cyclophosphamide, Vincristine Sulfate,         Prednisone) indicated for Non-Hodgkin Lymphoma     -   R-EPOCH (Rituximab, Etoposide Phosphate, Prednisone, Vincristine         Sulfate (Oncovin), Cyclophosphamide, Doxorubicin Hydrochloride         (Hydroxydaunomycin)) indicated for Non-Hodgkin Lymphoma     -   R-ICE (Rituximab, Ifosfamide, Carboplatin, Etoposide Phosphate)         indicated for Non-Hodgkin Lymphoma     -   STANFORD V (Mechlorethamine Hydrochloride, Doxorubicin         Hydrochloride, Vinblastine Sulfate, Vincristine Sulfate,         Bleomycin, Etoposide Phosphate, Prednisone) indicated for         Hodgkin Lymphoma     -   TAC (Docetaxel (Taxotere), Doxorubicin Hydrochloride         (Adriamycin), Cyclophosphamide) indicated for Breast Cancer     -   TPF (Docetaxel (Taxotere), Cisplatin (Platinol), Fluorouracil)         indicated for Gastric Cancer     -   TPF (Docetaxel (Taxotere), Cisplatin (Platinol), Fluorouracil)         indicated for Head and Neck Cancer     -   VAC (Vincristine Sulfate, Dactinomycin (Actinomycin-D),         Cyclophosphamide) indicated for Ovarian Cancer     -   VAC (Vincristine Sulfate, Dactinomycin (Actinomycin-D),         Cyclophosphamide) indicated for Soft Tissue Sarcoma     -   VAMP (Vincristine Sulfate, Doxorubicin Hydrochloride         (Adriamycin), Methotrexate, Prednisone) indicated for Hodgkin         Lymphoma     -   VeIP (Vinblastine Sulfate (Velban), Ifosfamide, Cisplatin         (Platinol)) indicated for Ovarian Cancer     -   VeIP (Vinblastine Sulfate (Velban), Ifosfamide, Cisplatin         (Platinol)) indicated for Testicular Cancer     -   VIP (Eroposide (VP-16), Ifosfamide, Cisplatin (Platinol))         indicated for Testicular Cancer     -   XELIRI (Capecitabine (Xeloda), Irinotecan Hydrochloride)         indicated for Colon Cancer     -   XELIRI (Capecitabine (Xeloda), Irinotecan Hydrochloride)         indicated for Esophageal Cancer     -   XELIRI (Capecitabine (Xeloda), Irinotecan Hydrochloride)         indicated for Gastric Cancer     -   XELIRI (Capecitabine (Xeloda), Irinotecan Hydrochloride)         indicated for Rectal Cancer     -   XELOX (Capecitabine (Xeloda), Oxaliplatin) indicated for Colon         Cancer     -   XELOX (Capecitabine (Xeloda), Oxaliplatin) indicated for Rectal         Cancer

While the above mentioned drugs are useful in treating cancer, such drugs produce significant side effects.

Medication induced side effects of chemotheraphy in a patient are related to the side effect of chemotherapy on rapidly dividing cells in addition to cancer cells. Some side effects are annoying and uncomfortable. Other side effects are dangerous and even life threatening. Chemotherapy side effects include Actinic Keratosis; Aggressive Systemic Mastocytosis; Acnemia (Low Red Blood Cells); Cacinoid Syndrome; Cardiac Toxicity; Condyloma Acuminatum (Genital Wards); Constipation; Cytokine Release Syndrome; Drug Extravasation (Drug Leakage in Tissues); Hemorrhage Cystitis (Bleeding in the Bladder); Hepatic Veno-occlusive Disease (Blocked Liver Veins); Hepatitis C Infection; Hypercalcemia of Malignancy (High Blood Calcium); Malignant Effusions; Mucositis (Inflamed Mucous Membranes); Nausea and Vomitting; Nerotoxicity (Nervous System Side Effects); Neutopenia (Low Blood Neutophils); Osteoporosis (Low Bone Density); Renal Toxicity (Kidney Side Effects); Skin Changes Due to Cutaneous Metastases; sepsis; Thrombocytopenia (Low Blood Platelets); Tumor Lysis Syndrome (Cell Breakdown and Organ Damage); and Chemotherapy Induced Febrile Neutopenia. Like a canary in a mine, certain parameters such as Chemotherapy induced Febrile Neutopenia, cytokine release storm, sepsis, changes in EKG, EEG, respiration, etc., are often early indications of adverse side effects. In particular, by sensing and recording changes in a patient's selected parameters, early intervention, e.g., through administration of oral antibiotics and/or a change in drug regiment may be prescribed.

The present invention relates to a system, i.e. method and apparatus for out-patient monitoring of development of medication induced side effects in a patient. The invention has particular utility in connection with the out-patient monitoring of chemotherapy induced febrile neutropenia, and will be described in connection with such utility, although other utilities are contemplated.

Immune dysregulation is a component of many pathological diseases or conditions. Such dysregulation may be a factor that favors the establishment, maintenance or progression of diseases or conditions. Immune response or immune suppression also frequently results from medication treatments including specifically chemotherapy that is used in the treatment of cancer.

Outpatient therapy for low-risk neutropenic patients is considered safe, but remains an uncommon practice. However, even with regular monitoring, including frequent in-office or outpatient monitoring, patients frequently get into trouble resulting in costly hospitalizations for treatment of chemotheraphy induced febrile neutropenia, since by the time the patient is diagnosed, it often is too late for treatment other than through administration of paranteral antibiotics.

Although the definition for chemotherapy induced febrile neutropenia vary across institutions and guidelines, most North American Societies define a single oral temperature of >38.3° C. (101.3° F.) or a temperature of >38° C. (100.4° F.) sustained for >1 hour as significant and neutropenia with an ANC<1000 cells/microL, whilst severe neutropenia is considered an absolute neutrophil count (ANC)<500 cells/microL, or an ANC that is expected to decrease to <500 cells/microL over the next 48 hours¹. In spite of the wide utilization of growth factors and prophylactic antimicrobial therapy in patients obtaining chemotherapy for their malignant disease, febrile neutropenia still remains a common treatment related complication². Early studies linked infections in the context of severe neutropenia with a substantial mortality rate³.

The corresponding concern of the development of an overwhelming sepsis episode rendered hospitalization with the administration of parenteral antibiotics as the standard of care in the management of patients with febrile neutropenia for many decades. It is now well recognized that neutropenic fever patients represent a very heterogeneous group⁴. The Multinational Association for the Supportive Care in Cancer (MASCC) proposed a seven point model, consisting of (1) degree of symptom burden, (2) presence or absence of hypotension, (3) need for IV fluid resuscitation, (4) presence or absence of COPD as a comorbidity, (5) solid tumor malignancy or hematologic malignancy without prior fungal infection, (6) outpatient status and (7) age above or below sixty years old as relevant clinico-demographic cofactors for the risk stratification of patients presenting with chemotherapy induced febrile neutropenia⁴. At least seven randomized trials have established the use of outpatient antibiotics as a safe and efficacious strategy in low risk febrile neutropenia⁵⁻¹¹. In addition, the comparability of oral with intravenous regimens has been demonstrated¹²⁻¹⁵. Several guidelines support the use of outpatient antibiotics in the low risk setting¹⁶⁻¹⁸. A recent systematic review with meta-analysis revealed equal mortality with inpatient versus outpatient therapy with comparables rates of treatment failure². Benefits of outpatient therapy in this setting include increased patient acceptance and the absence of exposure to a nosocomial environment. In addition, recent health economic comparisons of inpatient versus outpatient therapy in the low risk neutropenic feversetting have demonstrated striking savings with outpatient therapy^(19,20)

In spite of the available feasibility data and the benefits of outpatient therapy vs inpatient therapy described above, a large amount of patients with chemotherapy associated neutropenic fever are still admitted to the hospital for parenteral IV antibiotic therapy for the full length of their neutropenic presentation. A major reason for this is concern of further deterioration following the initial assessment at presentation.

SUMMARY OF THE INVENTION

The present invention provides a remote monitoring solution which permits out-patient early detection of chemotherapy associated febrile neutropenia and other early indications of adverse side effects, such as cytokine release storm, sepsis, pneumonitis, neurotoxicity, gastrointestinal toxicities, etc., and which often permits patients to be safely cared for in their own home environment, i.e. by early administration of oral antibiotics. An integrated algorithm captures early signs of deterioration, which might otherwise lead to hospitalization of the patient, and alerts the patient and medical personnel to begin administration or oral antibiotics before clinical characteristics render the patient a high-risk patient requiring hospitalization.

The multinational association for the supportive care in cancer patients (MASCC) proposes a weighted seven variable algorithm for the clinic-demographic assessment of a patient with chemotherapy related neutropenic fever⁴:

-   -   (1) degree of symptom burden     -   (2) presence or absence of hypotension     -   (3) need for IV fluid resuscitation     -   (4) presence or absence of COPD as a comorbidity     -   (5) solid tumor malignancy or hematologic malignancy without         prior fungal infection     -   (6) outpatient status     -   (7) age, i.e. above or below sixty years old

However, other, in certain aspects simpler algorithms have been proposed. The Infectious Diseases Society of America (IDSA) has proposed a ten point algorithm to stratify a patient with chemotherapy related febrile neutropenia as high or low risk. Any of the following clinical characteristics renders the patient as a high-risk patient¹.

-   -   1. ANC≤100 cells/microL expected to last >7 days     -   2. Hemodynamic instability     -   3. Oral or gastrointestinal tract mucositis limiting swallowing         or causing severe diarrhea     -   4. Gastrointestinal symptoms, such as abdominal pain, nausea and         vomiting, or diarrhea     -   5. Neurologic or mental status changes of new onset     -   6. Intravascular catheter infection     -   7. New pulmonary infiltrate or hypoxia     -   8. Underlying chronic lung disease     -   9. Evidence of hepatic insufficiency (defined as         aminotransferase levels >5 times normal values)     -   10. renal insufficiency (defined as a creatinine clearance <30         mL/min

In addition, the National Comprehensive Cancer Network (NCCN) proposes a more detailed breakdown of patients with chemotherapy related febrile neutropenia as high, intermediate or low risk²¹.

In addition to including an intermediate risk strata, the NCCN also includes the exposure to certain heavily immune-compromising anti-neoplastic agents (such as alemtuzumab) as risk factors.

High-risk—The NCCN categorizes febrile neutropenic patients as high-risk if any of the following criteria are met:

-   -   Inpatient status at time of development of fever     -   Significant medical comorbidity or presence of clinical         instability     -   Anticipated prolonged profound neutropenia (ANC≤100 cells/microL         expected to last >7 days)     -   Hepatic insufficiency (defined as aminotransferase levels >5         times normal values) or renal insufficiency (defined as a         creatinine clearance <30 mL/min)     -   Uncontrolled progressive cancer defined as any leukemic patient         not in complete remission, or any non-leukemic patient with         evidence of disease progression after more than two courses of         chemotherapy     -   Pneumonia or other complex infection at clinical presentation     -   Alemtuzumab exposure within the past two months     -   Grade 3 or 4 mucositis     -   Multinational Association for Supportive Care in Cancer (MAS CC)         risk index score     -   <21

Intermediate risk—In addition to the categories of high-risk and low-risk described above, the NCCN defines febrile neutropenic patients to be intermediate-risk for complications if any of the following criteria are met:

-   -   Autologous HCT     -   Lymphoma     -   Chronic lymphocytic leukemia     -   Multiple myelorna     -   Purine analog therapy     -   Anticipated duration of neutropenia of 7 to 10 days

Low-risk—The NCCN categorizes febrile neutropenic patients as low-risk for complications if they do not meet any of the high-risk criteria described above and if they meet most of the following criteria:

-   -   Outpatient status at time of development of fever     -   No associated acute comorbid illness requiring inpatient         hospitalization or close observation     -   Anticipated short duration of severe neutropenia (ANC≤100         cells/microL expected to last 7 days or fewer)     -   Good performance status (Eastern Cooperative Oncology Group         ˜ECOG1 0-1     -   No hepatic insufficiency     -   No renal insufficiency     -   Multinational Association for Supportive Care in Cancer (MASCC)         risk index score     -   ≥21

The present invention provides a system involving both hardware and software tools for monitoring and measuring a patient's health, and for assessing a change in a patient's condition, changing his/her risk status and the corresponding clinical approach.

Embodiments of the present disclosure provide systems and methods for home monitoring and detection of febrile neutropenia and/or monitoring and detection of other physical markers such as electrocardiographic parameters, respiration, etc., in a patient. Briefly described, in architecture, one embodiment of a system, among others, can be implemented as follows. The system includes a wearable photoplethysmographic sensor for sensing photoplethysmographic signals of the patient, and/or one or more blood borne parameter sensors for sensing parameters in the patient's blood, and/or one or more other sensors for measuring other physical markers of the patient. A patient monitoring application is hosted at least partially on a server and electronically accessible over at least one network system to a patient computer. The patient monitoring application is configured to receive information sensed by the physical sensor(s) and to determine, based on the received information, the presence or deterioration of a patient deteriorating condition.

In one embodiment, the system comprises a photoplemysmography sensor and a wearable movement sensor for sensing movement of the patient, wherein the photoplethysmographic signals are corrected based on information sensed by the movement sensor,

In another embedment, the system further comprises a healthcare provider computer, wherein the patient monitoring application is further configured to provide an alarm to the healthcare provider computer upon a determination of the presence or deterioration of febrile neutropenia in the patient.

In one embodiment, the patient monitoring application is further configured to provide an alarm to the healthcare provider computer upon a determination of patient non-compliance with a patient monitoring protocol.

In yet another embodiment the system further comprises a temperature sensor for sensing the patient's body temperature, wherein the patient monitoring application is further configured to receive information sensed by the temperature sensor and to determine the presence or deterioration of febrile neutropenia based at least in part on the sensed temperature information.

In still yet another embodiment, the system further comprises at least one of a sensor for measuring blood pressure and/or heart rate and/or pulse oxygen %, i.e., a pulse oximeter, and optinally a scale for measuring the patient's weight, wherein the febrile neutropenia monitoring application is configured to receive information sensed by the at least one of a blood pressure and/or heart rate and/or pulse ox, sensor and scale and to determine the presence or deterioration of febrile neutropenia based at least in part on the information sensed by the at least one of a blood pressure and/or heart rate and/or pulse ox sensor and scale.

In one embodiment the patient monitoring application is further configured to determine and monitor the patient's peripheral vascular resistance and heart rate based on the information sensed by the photoplethysmographic sensor, and/or to determine and monitor the patient's breathing rate, breathing depth and optionally a spirometer for measuring the patient's spironometric values, i.e., lung volume.

In yet another embodiment the patient monitoring sensors comprise blood borne parameter sensors for sensing or counting at least one of neutrophils and monocytes.

In still yet another embodiment the patient monitoring sensors comprise a multiplex biochemical assay for detecting at least one of: interleukin 1 and 6; tumor necrosis factor; procalcitonin; and C-reactive protein.

In yet another embodiment the patient monitoring application is further configured to provide a communication to the patient computer, upon a determination of the presence or deterioration of febrile neutropenia in the patient, said communication prompting the patient to perform at least one of: seeking professional medical care, and begin taking antibiotics.

In another embodiment, a method for home monitoring and detection of febrile neutropenia in a patient is provided that includes the steps of: sensing photoplethysmographic signals of the patient with a photoplethysmographic sensor worn by the patient; sensing blood borne parameters in the patient's blood with one or more blood borne parameter sensors; transmitting the sensed photoplethysmographic signals and blood borne parameters to a febrile neutropenia monitoring application; and determining, by the febrile neutropenia monitoring application, the presence or deterioration of febrile neutropenia based on the received information.

In one embodiment the method further comprises sensing movement of the patient with a wearable movement sensor; and correcting the photoplethysmographic signals based on information sensed by the movement sensor.

In another embodiment, the method comprises providing, by the febrile neutropenia monitoring application, an alarm to a healthcare provider computer upon a determination of the presence or deterioration of febrile neutropenia in the patient.

In yet another embodiment, the method further comprises providing, by the febrile neutropenia monitoring application, an alarm to a healthcare provider computer upon a determination of patient non-compliance with a patient monitoring protocol.

In still yet another embodiment, the method further comprises sensing the patient's body temperature with a temperature sensor, wherein the determining, by the febrile neutropenia monitoring application, of the presence or deterioration of febrile neutropenia is further based on the sensed temperature information.

In another embodiment, the method comprises sensing at least one of the patient's blood pressure and weight, wherein the determining, by the febrile neutropenia monitoring application, is further based on the at least one of a blood pressure and weight information.

In yet another embodiment, the method comprises determining, by the febrile neutropenia monitoring application, determine the patient's peripheral vascular resistance and heart rate based on the information sensed by the photoplethysmographic sensor.

In still yet another embodiment, the blood borne parameter sensors comprise a cell-based assay for sensing or counting at least one of neutrophils and monocytes.

In yet another embodiment, the blood borne parameter sensors comprise a multiplex biochemical assay for detecting at least one of: interleukin 1 and 6; tumor necrosis factor; procalcitonin; and C-reactive protein.

Yet another embodiment comprises providing, by the febrile neutropenia monitoring application, a communication to a patient computer, upon a determination of the presence or deterioration of febrile neutropenia in the patient, said communication prompting the patient to perform at least one of: seeking professional medical care, and begin taking antibiotics.

In yet another embodiment, a non-transitory computer readable medium is provided that contains instructions for home monitoring and detection of febrile neutropenia in a patient enabled at least in part on a processor of a computerized device, the instructions, which when executed by the processor, performing the steps of: receiving photoplethysmographic signals of the patient from a photoplethysmographic sensor worn by the patient; receiving blood borne parameters in the patient's blood from one or more blood borne parameter sensors; and determining the presence or deterioration of febrile neutropenia based on the information received from the photoplethysmographic sensor and the one or more blood borne parameter sensors.

Other systems, methods, features, and advantages of the present disclosure will be or become apparent to one with skill in the art upon examination of the following drawings and detailed description. It is intended that all such additional systems, methods, features, and advantages be included within this description, be within the scope of the present disclosure, and be protected by the accompanying claims.

BRIEF DESCRIPTION OF THE DRAWINGS

Many aspects of the disclosure can be better understood with reference to the following drawings. The components in the drawings are not necessarily to scale, emphasis instead being placed upon clearly illustrating the principles of the present disclosure. Moreover, in the drawings, like reference numerals designate corresponding parts throughout the several views.

FIG. 1 is a flow chart which schematically illustrates methods for evaluating whether a patient is suited for home monitoring for febrile neutropenia, in accordance with embodiments of the present disclosure.

FIG. 2 is a flow chart which schematically illustrates a method for home monitoring and detection of febrile neutropenia in a patient, in accordance with embodiments of the present disclosure.

FIG. 3 is a schematic illustration of a system for home monitoring and detection of febrile neutropenia, in accordance with embodiments of the disclosure.

DETAILED DESCRIPTION OF THE PRESENT INVENTION

The present invention employs peripheral point-of-care devices, such as described herein, which allow for home monitoring of certain patient's vital statistics, combined with computer-executable instructions, including algorithms executed by a programmable computer.

Many embodiments of the present invention may take the form of computer-executable instructions, including algorithms executed by a programmable computer. However, the invention can be practiced with other computer system configurations as well. Certain aspects of the invention can be embodied in a special-purpose computer or data processor that is specifically programmed, configured or constructed to perform one or more of the computer-executable algorithms described below. Accordingly, the term “computer” as generally used herein refers to any data processor and includes Internet appliances, hand-held devices (including palm-top computers, wearable computers, cellular or mobile phones, multi-processor systems, processor-based or programmable consumer electronics, network computers, minicomputers) and the like.

The invention also can be practiced in distributed computing environments, where tasks or modules are performed by remote processing devices that are linked through a communications network. Moreover, the invention can be practiced in Internet-bases or cloud computing environments, where shared resources, software and information may be provided to computers and other devices on demand. In a distributed computing environment, program modules or subroutines may be located in both local and remote memory storage devices. Aspects of the disclosure described below may be stored or distributed on computer-readable media, including magnetic and optically readable and removable computer disks, fixed magnetic disks, floppy disk drive, optical disk drive, magneto-optical disk drive, magnetic tape, hard-disk drive (HDD), solid state drive (SSD), compact flash or non-volatile memory, as well as distributed electronically over networks. Data structures and transmissions of data particular to aspects of the disclosure are also encompassed within the scope of the invention.

Neutropenic fever is defined by a physiology underlying the systemic inflammatory response syndrome (SIRS)²² and sepsis. Hence, deterioration is clinically indicated by a deterioration of the physiologic parameters defining the SIRS, i.e. along with the cell count parameters (neutrophil/monocyte count) also the pulse rate, respiration rate and temperature. Further deterioration is then indicated by evidence of hypo-perfusion and organ dysfunction^(22,23). This is evidenced by blood pressure drop, decrease in cardiac output, change in peripheral vascular resistance and occasionally disseminated intravascular coagulation as well as mental status deterioration and decreased renal function.

Many, if not all, of the hallmarks of the SIRS and most clinical signs of early deterioration are accessible by currently available peripheral point of care devices (PPCD).

In some embodiments provided herein, parameters assessed include:

-   -   Blood count     -   Body temperature     -   Pulse rate     -   Capillary CO2 tension     -   Blood pressure/Systemic Vascular Resistance

These physiologic parameters can be periodically or continuously measured on patients with neutropenic fevers. An integrated, unique algorithm signals early deterioration which ideally can be treated in the patient's home or the doctor's office before the deterioration becomes so severe as to lead to hospitalization.

FIG. 1 is a flowchart 100 illustrating methods for evaluating whether a patient is suited for home monitoring for medication induced febrile neutropenia, in accordance with an exemplary embodiment of the present disclosure. As shown at block 102, satisfaction of three initial criteria may be required before a further, initial assessment is performed on the patient. At block 104, an initial assessment is performed, which includes various assessments and/or analysis, including: a complete physical exam; CBS and CMP; urinalysis; lactic acid; microbiologic assessment; CXR if clinically indicated; and a risk assessment with MASCC score.

If results from the initial assessment indicate that the patient meets a low-risk MSACC score, further criteria may require satisfaction before deeming the patient suitable for remote home monitoring, as shown at block 106. Such criteria may include: the presence of a solid tumor; the patient lives within 1 hour (or some other suitable time/distance) of the treating center/physician; ability to tolerate oral medications and fluids; does not use PEG as route for nutrition; not currently on antibiotics; at least 18 years of age; and no quinolone allergy for oral regimens.

If it is determined that a patient is well-suited for home monitoring, e.g., after satisfaction of the evaluation as shown in FIG. 1, the patient may begin home monitoring for medication induced febrile neutropenia, as shown in FIG. 2. FIG. 2 is a flowchart 200 illustrating a method for home monitoring of a patient for medication induced febrile neutropenia, in accordance with embodiments provided by this disclosure.

As shown at 202, a patient's health parameters are monitored using one or more point-of-care monitoring devices. As shown at 204, monitored health parameters may include, for example: a daily measurement of complete blood count (CBC); continuous measurement of body temperature; continuous measurement of pulse rate; continuous measurement of capillary O₂; repeated measurement of blood pressure; and continuous measurement of systemic vascular resistance.

Various peripheral point-of-care devices exist for home monitoring of health parameters of a patient, and may be included in the systems and methods provided herein for home monitoring of a patient for medication induced febrile neutropenia. These include blood pressure monitors available from A & D and other vendors, blood glucose monitors available from MyClinicalHealth, Lifescan J & J and other vendors, thermometers available from Cardi Scientific and other vendors, pulse oximeters (pulse ox meters) available from Nonin and other vendors, peak flow monitors available from Microlife and other vendors, pedometers available from Omron and other vendors, and weight scales available from A & D Medical and other vendors. Many of these devices have been around for years. More recently point-of-care cell analyzers have been developed for blood cell counting and moving from the laboratory to home use. See “Integrated Systems for Rapid Point of Care (POC) Blood Cell Analysis” by vanBarkel et al, The Royal Society of Chemistry 2010, the entirety of which is incorporated herein by reference.

Many of the currently available monitors are fully automated and require no patient intervention. Others require simple prompting by the patient. Mass production of these monitors also has brought the cost of such monitors down significantly. By way of example Apple® and other smart watches include ECG capabilities as well as heart rate, blood pressure and blood oxygen monitoring and measurement capabilities. Several commercially available monitors include communication capabilities also for communicating with the computer either through hard wiring, or wirelessly. As the cost of computers also continues to fall, there presents an opportunity to reduce patient risks and costs, and at the same time improve patient outcome.

The health monitoring devices may be worn by the patient continuously while in an outpatient setting, such as at the patient's home, thereby providing continuous monitoring of the various health parameters. Alternatively, the patient may be prompted, e.g. by a timer or the like to periodically don the monitors for a reading. In order to ensure patient compliance, in an embodiment, one or more of the monitors may communicate, for example, wirelessly, to a central computer which would alert health care personnel if the patient fails to timely present his or herself for monitoring.

Information sensed by the healthcare monitoring devices may be processed by an algorithm, at 206, to determine a state of the patient's health, such as the presence of, or risk of developing, febrile neutropenia. The healthcare monitoring devices and/or a computer system running the algorithm may then provide an alert to health care personnel if the parameters assessed by the devices indicate clinical signs of early deterioration of the patient's health, at 208. Where early clinical signs of patient health deterioration are determined, the patient may be prompted to seek professional medical care (e.g., such as admission to a hospital, at 210) or to begin taking oral antibiotics which could be supplied to the patient ahead of time, or supplied, e.g. by a pharmacy, which may also be prompted by the system to dispense a course of antibiotics. Also, again to ensure patient compliance, the health care professional may be advised of a patient's health deterioration so that the health care professional could contact the patient if the patient does not make the contact first.

FIG. 3 is a schematic illustration of a system for home monitoring and detection of febrile neutropenia 30, in accordance with an exemplary embodiment of the present disclosure. The system for home monitoring and detection of febrile neutropenia 30, which may also be referred to as ‘system 30’, includes a febrile neutropenia monitoring application 325, which may be electronically accessible over at least one network system 312 and hosted at least partially on a server 320. A patient computer 35 is positioned to access the application 325, and a healthcare provider computer 55 may further be positioned to access the application 325. The system 30 further includes a variety of patient monitoring devices 340, which may include a photoplethysmographic sensor 342, movement sensor 344 and one or more blood borne parameter sensors 346.

The server 320 may be or include any database capable of storing and/or providing access to information, such as an electronic database, a computer and/or computerized server, database server or generally any network host capable of storing data and connected to any type of data network. Further, the server 320 may include or be a part of a distributed network or cloud computing environment. Any type of electronic and/or computerized device that is capable of storing information may be included as the server 320, and is considered within the scope of this disclosure. The server 320 may include computer-readable storage media, and a processor for processing data and executing algorithms, including any of the processes and algorithms set forth in this disclosure. The febrile neutropenia monitoring application 325 is electronically accessible over at least one network system 312. The network system 312 may include any type of network infrastructure, such as the Internet, or any other wired, wireless and/or partially wired network. The server 320, application 325 and network system 312 may include a variety of hardware and software components to provide successful functioning of the server 320 and the application 325, as is well-known within the art. Further, any features, characteristics, designs and/or functions that are known within the art may be included with the system 30 to further enhance its efficiency.

The patient computer 35 may be any computerized device that is capable of communicating with the application 325, for example via a network system 312, and may be operated by any patient for home monitoring of febrile neutropenia, or any representative thereof. Similarly, the healthcare provider computer 55 may be any computerized device that is capable of communicating with the application 325, for example via a network system 312, and may be operated by any physician, nurse or other healthcare provider, or any representative thereof. Any number of patient computers 35 and healthcare provider computers 55 may use the system 30 at any given time. The patient computer 35 and healthcare provider computer 55 may access the application 325 through a variety of ways, including through a computerized device in communication with the system 30 over a network system. For example, the patient computer 35 and/or healthcare provider computer 55 may be any computer, including any personal computer, Internet appliance, hand-held device (including palm-top computers, wearable computers, cellular or mobile phones, ipads, multi-processor systems, processor-based or programmable consumer electronics, network computers, minicomputers) and the like. One or more input devices, such as a keyboard or mouse, may be used to transmit information to and/or request information from the application 325 by the patient computer 35 and/or the healthcare provider computer 55.

The system 30 includes a plurality of point-of-care devices for monitoring or sensing parameters related to a patient's health (e.g., patient monitoring devices 340), which may be wearable monitoring devices that are operationally worn on the patient for measuring selected parameters as described herein. Readings from the patient monitoring devices 340 are transmitted to a computer (e.g., patient computer 35 and/or server 320) which includes or accesses the febrile neutropenia monitoring application 325 for monitoring and evaluating changes in the patient's vital statistics. The information sensed by the patient monitoring devices 340 may be transmitted directly to the server 320, or may be transmitted to the patient computer 35 (e.g., a patient's home-based computer, such as a laptop, desktop computer, smartphone or the like) which then communicates the sensed information to the application 325.

The febrile neutropenia monitoring application 325 may be fully or partially hosted on the server 320. Alternatively, the application 325 may be hosted and/or accessed on a patient's local computer, such as patient computer 35. The febrile neutropenia monitoring application 325 may include any tool, device, system, process or combination thereof, which assists or makes possible determining when a patient's measured parameters are approaching or are out of compliance with pre-determined criteria suggesting the onset or presence of febrile neutropenia, or deterioration of health in a patient with febrile neutropenia. The application 325 may include any computer-readable memory or databases, which may be stored in any computer-readable medium, and may be accessible by a computer processor. The application 325 may further include or access computer program instructions which may cause a processor to perform any algorithms and/or functions which may be described in this disclosure.

Further, the application 325 may provide access to a web or network-based platform, including a graphical user interface or webpage which provides interactive access to the system 30 to a user of a patient computer 35 and/or a healthcare provider computer 55. Alternatively or additionally, a patient computer 35 and/or healthcare provider computer 55 may include software providing access to the system 30.

The photoplethysmographic sensor 342 may be, for example, a wearable pulse oximeter. A wearable movement sensor 344 may be included to correct motion and/or gravitational interferences in the patient's photoplethysmographic signal. The patient's peripheral vascular resistance and the change in the peripheral vascular resistance may be determined from information sensed by the photoplethysmographic sensor 342. The patient's heart rate, an important vital parameter for the detection of febrile neutropenia and deterioration in febrile neutropenia, may be provided and/or determined (e.g., by the application 325) from the frequency of the photoplethysmographic signal. The patient's temperature may be recorded by a temperature sensor and transmitted to the application 325, as temperature may serve as a factor for the detection of febrile neutropenia and deterioration in febrile neutropenia. The patient monitoring devices 340 may further include a blood pressure sensor, such as a blood pressure cuff, and a scale for measuring the patient's weight. Additional patient monitoring devices 340 may be included for monitoring any health-related parameter which may be relevant to the determination of febrile neutropenia or deterioration of febrile neutropenia, including, for example, devices for monitoring or sensing any of the parameters listed at block 204 of FIG. 2.

Physiological parameters (e.g., as sensed by the photoplethysmographic sensor 342) may be correlated in real-time with blood borne parameters, such as sensed by blood borne parameter sensors 346. The blood borne parameter sensors 346 may include or utilize LFIRE (Label-Free Internal Reflection Ellipsometry) by Maven Technologies, LLC, as disclosed at least in part in one or more of the following U.S. Pat. Nos., each of which are incorporated in their entireties herein by reference: U.S. Pat. Nos. 6,594,011; 7,023,547; 6,859,280; 6,882,420; 7,002,686; 7,193,711; 7,518,724; 8,039,270; and 8,355,133.

The blood borne parameter sensors 346 may include cell-based assays for sensing or counting neutrophils and/or monocytes in a sample of the patient's blood, and may further include sensors for multiplex biochemical assays for simultaneous detection of binding events to nucleic acid or protein microarray on the sensor surface. Such multiplex biochemical assays may detect parameters relevant to a determination of febrile neutropenia or deterioration of febrile neutropenia such as: interleukin 1 and 6; tumor necrosis factor; procalcitonin; and C-reactive protein.

When neutropenia is suggested, the system 30 may raise an alarm prompting the patient or patient's caregiver to administer oral antibiotics and/or prompting the patient to seek medical care. For example, the application 325, upon determining that the information sensed by the patient monitoring devices 340 indicates the presence or deterioration of febrile neutropenia, may initiate an alarm or other communication to be transmitted to a healthcare provider computer 55.

By sensing and recording changes in a patient's selected parameters, early intervention, e.g. through administration of oral antibiotics may be prescribed. As a result, hospitalization of the patient may be avoided.

In a survey study, which was initially presented at the yearly ASCO meeting in 2004, 82% of physicians have claimed to treat some or all of their low-risk febrile neutropenic patients as outpatients while 17% exclusively used inpatient treatment²⁴. Despite existing guidelines, 18 only one third of the responding physicians complied with the evidence based pattern of care²⁴. Similar observation has been reported from studies in Canada and the UK, with the lowest acceptance towards outpatient treatment in low risk patients being observed in Europe^(25,26).

Elting presented a retrospective analysis of 712 patients²⁷, who were prospectively treated on the University of Texas MD Anderson Cancer Center low-risk neutropenic fever algorithm pathway¹⁵ ²⁸. The patients, who were treated as outpatients were compared to a small subset of patients who were on clinical assessment candidates for the outpatient pathway, but were deemed on the grounds of psychosocial criteria, such as absence of access to caregivers at home, no telephone or no transportation in case of emergency or a history of non-compliance with other outpatient regimens not to be eligible for treatment as outpatients. Treatment as outpatient was in average associated with savings of 7.432$ in costs per neutropenic fever episode (15.231,$ vs 7.799$)²⁷.

Hendricks¹⁹ evaluated the differences in costs between the in- and out-patient population in Talcott's randomized controlled trial¹¹. This analysis included all financial aspects incurred by a patient with acute febrile neutropenic fever episode, including along with billing information from hospitals, outpatient clinicians and home care providers also indirect costs such as informal caregivers' time expense (family labor)¹⁹. Again, a striking difference between charges for the hospital vs home based care were observed with 15.495$ vs 7.868$. Even including indirect costs, such as opportunity costs for family members, the difference still remained highly significant 16.341$ vs 10.977$ (P<0.0 1), with basically identical clinical complication rates.

Teuffel's cost effectiveness analysis in the context of the Canadian health system²⁰ compared four different approaches, entire in hospital management with IV antibiotics until neutrophil recovery (HospIV), early discharge after a limited course of in hospital IV antibiotics, followed by home PO antibiotics (EarlyDC), entire outpatient management with IV antibiotics (HomeIV) and entire outpatient management with PO antibiotics (HomePO). The mean costs for the different approaches were 13.557 C$, 6.15 C$, 4.83 C$ and 3.470 C$, reflecting a significant cost savings in each of the outpatient based treatment paradigms. The corresponding probabilistic willingness-to-pay analysis, which used a Canadian standard of 4.000 C$ for quality of life adjusted febrile neutropenia episode, revealed cost effective results in 1% HospIV, 8% EarlyDC 38% HomeIV and 54% HomePO of all simulated outcomes, respectively²⁰.

Various other physiologic parameters or markers may be monitored and evaluated, including but not limited to:

Markers:

1. Continuously measured electrocardiographic parameters (may also be more accurately measured repeatedly using separate, 6 lead electrocardiograph):

-   -   1. Three classes of heartbeats:         -   a. normal beat         -   b. ventricular beat, including:             -   i. premature ventricular contraction             -   ii. ventricular escape beat         -   c. supraventricular beat, including:             -   i. aberrated atrial premature beat             -   ii. nodal (junctional) premature beat             -   iii. atrial premature contraction             -   iv. nodal (junctional) escape beat             -   v. atrial escape beat.     -   2. Rhythms:         -   a. normal sinus rhythm         -   b. sinus bradycardia         -   c. sinus tachycardia         -   d. supraventricular rhythm         -   e. atrial bigeminy         -   f atrial trigeminy         -   g. atrial fibrillation         -   h. atrial flutter         -   i. supraventricular tachycardia         -   j. supraventricular couplet         -   k. idioventricular rhythm         -   l. ventricular bigeminy         -   m. ventricular trigeminy         -   n. ventricular fibrillation         -   o. ventricular flutter         -   p. ventricular bradycardia         -   q. ventricular tachycardia         -   r. ventricular couplet.     -   3. Heart rate variability analysis:         -   a. time-domain methods (AVNN, VARNN, SDNN, SDANN, RMSSD,             SDSD, NN50, pNN50)         -   b. geometric methods (NN histogram, HRV triangular index)         -   c. frequency-domain methods (LF, HF)         -   d. non-linear methods (detrended fluctuation analysis,             entropy analysis)

Other Markers:

-   -   1. Continuous electroencephalography         -   a. Relative power and coherence of frequency bands measuring             -   i. Delta waves (<4 Hz)             -   ii. Theta waves (≥4 Hz and <8 Hz)             -   iii. Alpha waves (≥8 Hz and <14 Hz in posterior regions                 of head)             -   iv. Beta waves (≥14 Hz and <32 Hz)             -   v. Gamma waves (≥32 Hz)             -   vi. Mu waves (≥8 Hz and <12 Hz in sensorimotor cortex)     -   2. Continuous beat-to-beat blood pressure (distinct from         repeated blood pressure measurement)     -   3. Repeated spirometer measurement         -   a. Spirometric values             -   i. FVC—Forced vital capacity; the total volume of air                 that can be exhaled during a maximal forced expiration                 effort.             -   ii. FEV1—Forced expiratory volume in one second; the                 volume of air exhaled in the first second under force                 after a maximal inhalation.             -   iii. FEV1/FVC ratio—The percentage of the FVC expired in                 one second.             -   iv. FEV6—Forced expiratory volume in six seconds.             -   v. FEF25-75%—Forced expiratory flow over the middle one                 half of the FVC; the average flow from the point at                 which 25 percent of the FVC has been exhaled to the                 point at which 75 percent of the FVC has been exhaled.             -   vi. MVV—Maximal voluntary ventilation.         -   b. Lung volumes             -   i. ERV—Expiratory reserve volume; the maximal volume of                 air exhaled from end-expiration.             -   ii. IRV—Inspiratory reserve volume; the maximal volume                 of air inhaled from end-inspiration.             -   iii. RV—Residual volume; the volume of air remaining in                 the lungs after a maximal exhalation.             -   iv. VT—Tidal volume; the volume of air inhaled or                 exhaled during each respiratory cycle.         -   c. Lung capacities             -   i. FRC—Functional residual capacity; the volume of air                 in the lungs at resting end-expiration.             -   ii. IC—Inspiratory capacity; the maximal volume of air                 that can be inhaled from the resting expiratory level.             -   iii. TLC—Total lung capacity; the volume of air in the                 lungs at maximal inflation.             -   iv. VC—Vital capacity; the largest volume measured on                 complete exhalation after full inspiration.     -   4. Continuous measurement of temperature parameters         -   a. temperature trajectory measured from an initial point             (the temperature value at some time defined as 0) and form             (shape defined by a mathematical function), as well as rate             of change (speed), and change in rate (acceleration)         -   b. Standard deviation of temperature         -   c. temperature differential calculated between multiple             continuous measurements taken by wearable sensors     -   5. Continuous measurement of respiratory rate via wearable         accelerometer     -   6. Repeated lactate measurement via blood gas analysis devices         equipped with a lactate measuring electrode     -   7. Repeated measurement of cytokine interleukin-3 (IL-3) levels         in blood plasma     -   8. Repeated procalcitonin (PCT) measurement     -   9. Repeated measurement of circulating tumor cells (CTC)         Additional indications/effects detected:     -   Cytokine release storm     -   Sepsis     -   Pneumonitis     -   Acute pulmonary toxicity     -   Cardiac toxicities     -   Gastric toxicities     -   Neurotoxicity         All of the above indications/effects may be monitored and         measured on an out-patient basis using wearables, or portable         in-home use devices such as weight scales, spirometers, or         simple automated blood or saliva, etc., testers, which are         configured to report readings directly or indirectly to a         patient computer.

It should be emphasized that the above-described embodiments of the present invention, particularly, any “preferred” embodiments, are merely possible examples of implementations, merely set forth for a clear understanding of the principles of the invention. Many variations and modifications may be made to the above-described embodiment(s) of the invention without departing substantially from the spirit and principles of the invention.

All such modifications and variations are intended to be included herein within the scope of this invention and the present invention and protected by the following claims.

REFERENCES

Each of the following references are incorporated in their entireties herein, by reference:

-   1. Freifeld, A. G. et al. Clinical practice guideline for the use of     antimicrobial agents in neutropenic patients with cancer: 2010     update by the infectious diseases society of America. Clinical     infectious diseases: an official publication of the Infectious     Diseases Society of America 52, e56-93 (2011). -   2. Teuffel, O., Ethier, M C., Alibhai, S. M. H., Beyene, J. &     Sung, L. Outpatient management of cancer patients with febrile     neutropenia: a systematic review and meta-analysis. Annals of     oncology: official journal of the European Society for Medical     Oncology/ESAJO 22, 2358-65 (2011). -   3. Bodey, G. P., Buckley, M., Sathe, Y. S. & Freireich, E. J.     Quantitative relationships between circulating leukocytes and     infection in patients with acute leukemia. Annals of internal     medicine 64, 328-40 (1966). -   4. Klastersky, J. et al. The Multinational Association for     Supportive Care in Cancer risk index: A multinational scoring system     for identifying low-risk febrile neutropenic cancer patients.     Journal of clinical oncology: official journal of the American     Society of Clinical Oncology 18, 3038-51 (2000). -   5. Hidalgo, M. et al. Outpatient therapy with oral ofloxacin for     patients with low risk neutropenia and fever: a prospective,     randomized clinical trial. Cancer 85, 2 13-9 (1999). -   6. Malik, I. A., Khan, W. A., Karim, M., Aziz, Z. & Khan, M. A.     Feasibility of outpatient management of fever in cancer patients     with low-risk neutropenia: results of a prospective randomized     trial. The American journal of medicine 98, 224-31 (1995). -   7. Rapoport, B. L. et al. Ceftriaxone plus once daily aminoglycoside     with filgrastim for treatment of febrile neutropenia: early hospital     discharge vs. Standard In-patient care. Chemotherapy 45, 466-76 -   8. Innes, H. E. et al. Oral antibiotics with early hospital     discharge compared with in-patient intravenous antibiotics for     low-risk febrile neutropenia in patients with cancer: a prospective     randomised controlled single centre study. British journal of cancer     89, 43-9 (2003). -   9. Santolaya, M. E. et al. Early hospital discharge followed by     outpatient management versus continued hospitalization of children     with cancer, fever, and neutropenia at low risk for invasive     bacterial infection. Journal of clinical oncology: official journal     of the American Society of Clinical Oncology 22, 3784-9 (2004). -   10. Ahmed, N. et al. Early hospital discharge versus continued     hospitalization in febrile pediatric cancer patients with prolonged     neutropenia: A randomized, prospective study. Pediatric blood &     cancer 49, 786-92 (2007). -   11. Talcott, J. A. et al. Safety of early discharge for low-risk     patients with febrile neutropenia: a multicenter randomized     controlled trial. Journal of clinical oncology: official journal of     the American Society of Clinical Oncology 29, 3 977-83 (2011). -   12. Gupta, A., Swaroop, C., Agarwala, S., Pandey, R. M. &     Bakhshi, S. Randomized controlled trial comparing oral     amoxicillin-clavulanate and ofloxacin with intravenous ceftriaxone     and amikacin as outpatient therapy in pediatric low-risk febrile     neutropenia. Journal of pediatric hematology/oncology 31,     635-41(2009). -   13. Minotti, V. et al. Domiciliary treatment of febrile episodes in     cancer patients: a prospective randomized trial comparing oral     versus parenteral empirical antibiotic treatment. Supportive care in     cancer: official journal of the Multinational Association of     Supportive Care in Cancer 7, 134-9 (1999). -   14. Sebban, C. et al. Oral moxifloxacin or intravenous ceftriaxone     for the treatment of low-risk neutropenic fever in cancer patients     suitable for early hospital discharge. Supportive care in cancer:     official journal of the Multinational Association of Supportive Care     in Cancer 16, 10 17-23 (2008). -   15. Rubenstein, E. B. et al. Outpatient treatment of febrile     episodes in low-risk neutropenic patients with cancer. Cancer 71,     3640-6 (1993). -   16. Segal, B. H. et al. Prevention and treatment of cancer-related     infections. Journal of the National Comprehensive Cancer Network:     JNCCN6, 122-74 (2008). -   17. Jun, H. X. et al. Clinical guidelines for the management of     cancer patients with neutropenia and unexplained fever.     International journal of antimicrobial agents 26 Suppl 2, S 128-32;     discussion S 133-40 (2005). -   18. Hughes, W. T. et al. 2002 guidelines for the use of     antimicrobial agents in neutropenic patients with cancer. Clinical     infectious diseases: an official publication of the Infectious     Diseases Society of America 34, 730-51 (2002). -   19. Hendricks, A. M., Loggers, E. T. & Talcott, J. A. Costs of home     versus inpatient treatment for fever and neutropenia: analysis of a     multicenter randomized trial. Journal of clinical oncology: official     journal of the American Society of Clinical Oncology 29, 3984-9     (2011). -   20. Teuffel, O., Amir, E., Alibhai, S., Beyene, J. & Sung, L. Cost     effectiveness of outpatient treatment for febrile neutropaenia in     adult cancer patients. British journal of cancer 104, 1377-83(2011). -   21. National Comprehensive Cancer Network (NCCN) Clinical Practice     Guidelines in Oncology. Prevention and treatment of cancer-related     infections. http://www.nccn.org (2011). -   22. Levy, M. M. et al. 2001 SCCM/ESICM/ACCP/ATS/SIS International     Sepsis Definitions Conference. Critical care medicine 31, 125 0-6     (2003). -   23. Annane, D., Bellissant, F. & Cavaillon, J.-M. Septic shock.     Lancet 365, 63-78 -   24. Freifeld, A., Sankaranarayanan, J., Ullrich, F. & Sun, J.     Clinical practice patterns of managing low-risk adult febrile     neutropenia during cancer chemotherapy in the USA. Supportive care     in cancer: official journal of the Multinational Association of     Supportive Care in Cancer 16, 18 1-91 (2008). -   25. Innes, H., Billingham, L., Gaunt, C., Steven, N. & Marshall, E.     Management of febrile neutropenia in the United Kingdom: time for a     national trial? British journal of cancer 93, 1324-8 (2005). -   26. Sung, L. et al. Inpatient versus outpatient management of     low-risk pediatric febrile neutropenia: measuring parents' and     healthcare professionals' preferences. Journal of clinical oncology:     official journal of the American Society of Clinical Oncology 22,     3922-9 (2004). -   27. Elting, L. S. et al. Outcomes and cost of outpatient or     inpatient management of 712 patients with febrile neutropenia.     Journal of clinical oncology: official journal of the American     Society of Clinical Oncology 26, 606-11(2008). -   28. Escalante, C. P. et al. Outcomes of treatment pathways in     outpatient treatment of low risk febrile neutropenic cancer     patients. Supportive care in cancer: official journal of the     Multinational Association of Supportive Care in Cancer 12, 657-62     (2004). 

1. A system for out-patient, home monitoring and detection of chemotherapy induced adverse side effects in a patient, the system comprising: one or more patient physical parameters sensors selected from: a temperature sensor for sensing patient temperature; a pulse oximeter for sensing photoplethysmographic signals of the patient; a movement sensor for sensing movement of the patient and for correcting for motion and/or gravitational interferences in the patient's photolethysmographic signals resulting from said sensed movements; a breathing sensor for sensing patient breathing rate, breathing depth and lung volume; a heart monitor for sensing heart rate, blood pressure, blood oxygen level and/or electrocardiogram functions; one or more point-of-care blood borne parameter sensors for sensing parameters in the patient's blood including neutrophil count; a weight scale for measuring the patient's weight; and a febrile neutropenia monitoring application; wherein the one ore more patient physical parameter sensors are hosted at least partially on a server and electronically accessible over at least one network system to a patient computer, wherein the home monitoring and detection system is configured to determine the patient's peripheral vascular resistance and heart rate based on information sensed by the pulse oximeter, and/or to receive information sensed by the temperature sensor, and/or the one or more blood borne parameter sensors, and/or the weight scale, the heart monitor, the patient breathing sensor, the movement sensor and the one or more point-of-care blood borne parameter sensors, and to determine, based on the received information, a change in the patient's condition, and should said change approach or be out of compliance with pre-determined criteria, indicative of the possible presence or deterioration of chemotherapy induced advser side effects in the patient, provide an alarm to a heathcare provider and/or the patient upon a determination of the presence of or deterioration of patient physical parameters in a patient.
 2. The system of claim 1 further comprising a healthcare provider computer located remotely from the patient's home, wherein the febrile neutropenia monitoring application is configured to provide an alarm to the healthcare provider computer upon a determination of the presence or deterioration of febrile neutropenia in the patient.
 3. The system of claim 2, wherein the febrile neutropenia monitoring application is configured to provide an alarm to the healthcare provider computer upon a determination of patient non-compliance with a patient monitoring protocol.
 4. The system of claim 1, further comprising a blood pressure sensor, wherein the febrile neutropenia monitoring application is configured to receive information sensed by the blood pressure sensor and to determine the presence or deterioration of febrile neutropenia based at least in part on the information sensed by the blood pressure sensor.
 5. The system of claim 1, wherein the blood borne parameter sensors comprise a cell-based assay for sensing or counting monocytes.
 6. The system of claim 1, wherein the febrile neutropenia monitoring application is configured to provide an alarm to the patient computer, upon a determination of the presence or deterioration of febrile neutropenia in the patient, said alarm prompting the patient to perform at least one of: seeking professional medical care, and begin taking antibiotics.
 7. The system of claim 1, wherein the heart monitor comprises a smart watch.
 8. The system of claim 1, wherein the chemotherapy induced adverse side effects are cancer treatment related adverse side effects.
 9. A method for out-patient home monitoring and detection of chemotherapy induced adverse side effects in a patient, the method comprising: sensing one or more of the following patient physical parameters: the patent's body temperature with a temperature sensor; sensing photoplethysmographic signals of the patient including vascular resistance, heart rate and blood oxygen saturation with a pulse oximeter; sensing patient breathing rate, breathing depth and/or lung volume; sensing movement of the patient and correcting for motion and/or gravitational interferences of the patient's photoplethysmographic signals resulting from said sensed movement; sensing heart rate, blood pressure, blood oxygen level and/or electrocardiogram functions; sensing the patient's weight with a scale; sensing blood borne parameters in the patient's blood, including neutrophil count, with one or more point-of-care blood borne parameter sensors; transmitting the sensed parameter(s) to a patient physical parameter monitoring application; determining, based on changes in the sensed patient physical parameter(s), if said signals are approaching or out of compliance with pre-determined criteria, indicative of the presence or deterioration of chemotherapy induced adverse side effects; and providing an alarm to a healthcare provider and/or the patient upon a determination of the presence of or deterioration of patient physical parameters in a patient.
 10. The method of claim 9, further comprising: providing, by the febrile neutropenia monitoring application, an alarm to a healthcare provider computer located remotely from the patient's home upon a determination of the presence or deterioration of febrile neutropenia in the patient.
 11. The method of claim 9, further comprising: providing, by the febrile neutropenia monitoring application, an alarm to a healthcare provider computer upon a determination of patient non-compliance with a patient monitoring protocol.
 12. The method of claim 9, further comprising: sensing the patient's blood pressure, wherein the determining, by the febrile neutropenia monitoring application, is based on changes in the blood pressure information.
 13. The method of claim 9, wherein the blood borne parameter sensors comprise a cell-based assay for sensing or counting at least one of neutrophils and monocytes.
 14. The method of claim 9, further comprising: providing, by the febrile neutropenia monitoring application, an alarm to a patient computer, upon a determination of the presence or deterioration of febrile neutropenia in the patient, said alarm prompting the patient to perform at least one of: seeking professional medical care and begin taking antibiotics.
 15. The method of claim 9, wherein the chemotherapy induced adverse side effects are cancer treatment related adverse side effects.
 16. A non-transitory computer readable medium containing instructions for home monitoring and detection of chemotherapy induced adverse side effects in a patient enabled at least in part on a processor of a computerized device, the instructions, which when executed by the processor, performing the steps of: receiving readings of one or more patient physical parameters including: receiving body temperature readings of the patient; receiving photoplethysmographic signals of the patient including vascular resistance, heart rate and blood oxygen saturation from a pulse oximeter; receiving correction signals for the photoplethysmographic signals based on sensed movement of the patient; receiving heart rate, blood pressure, blood oxygen level and/or electrocardiogram function signals of the patient; receiving patient body weight signals from a scale; receiving blood borne parameters including neutrophil count in the patient's blood from one or more point-of-care blood borne parameter sensors; receiving patent breathing rate, breathing depth and/or lung volume signals; determining if said readings are approaching or out of compliance with pre-determined conditions, indicative of the presence or deterioration of chemotherapy induced adverse side effects based on changes in the signals received from the sensor(s); and providing an alarm to a healthcare provider and/or the patient upon a determination of the presence or deterioration of chemotherapy induced adverse side effects in the patient.
 17. The non-transitory computer readable medium of claim 16, wherein the chemotherapy induced adverse side effects are cancer treatment related adverse side effects. 